Both Biotiva Transmax and Vindure 900 from Vinomis Laboratories are quality Resveratrol products.

So what’s the difference?

1. Amount of Resveratrol

Boitivia Transmax = 500 mg of 98% pure Resveratrol, total active ingredients = 500 mg

Vindure 900 = 400 mg of 98% pure Resveratrol, total active ingredients = 900 mg

**Numerous studies have placed the recommended human Resveratrol dosage in the 400 – 500 mg per day range. So both products provide good quantity, and good quality. Vindure 900 has almost twice the total amount of active ingredients.

2. Red Wine Grape Extract

Biotivia Transmax = None

Vindure 900 = 400 mg with 90% polyphenols

**Why? Harvard scientists discovered that 17 different polyphenols, all found in Red Wine Grapes, product positive health effects. Resveratrol was #1, but the others were equally important. Vindure 900 contains all 17 of these polyphenols. Scientist have also proved that the different polyphenols interact together to provide health benefits.

3. Bioavailability

Biotivia Transmax = No Quercetin

Vindure 900 = 100 mg Quercetin

**Quercetin has been found, in numerous studies, to increase the “bioavailability” of Resveratrol — which is the amount of time in the blood stream.

4. Price

Biotivia Transmax = $74.95 for 2-month supply = $37.50 per month

Vindure 900 = $39.95 per month or $33.33 per month on 3-month re-order program

**Prices are about the same.

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If you’re buying a Resveratrol Supplement, check the Supplement Facts on the label.

What if you can’t find the Supplement Facts? — Don’t buy that product

Should the Supplement Facts be on the Website? — Absolutely.

There are many Resveratrol products that “hide” their ingredients and quantities because they are of lesser grade, and lower quantity. Don’t be fooled — check the label.

Below are the Supplement Facts for Vindure 900:

Vindure™ 900 

Dietary Supplement – 30 Tablets 

A unique blend of Vinomis™ Red Wine Grape 

Extract, Pure Resveratrol, and Quercetin, 

Supplement Facts 

Serving Size: 1 Tablet 

Amount Per Tablet %DV 

Vinomis™ Red Wine Grape Extract 

with over 90% Polyphenols** 400mg *  

98% Pure Resveratrol 400mg * 

Quercetin 100mg * 

* Daily value not established 

Other Ingredients: Cellulose, Titanium Dioxide (Natural Mineral 

Whitener) and Chlorophyll Coloring from vegetable sources. 

**Contains PowerGrape® from Naturex 

These statements have not been evaluated 

by the Food and Drug Administration.  This 

product is not intended to diagnose, treat, 

cure, or prevent any disease.

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While testosterone hormones are associated with men, and estrogen with women, both men and women have levels of testosterone and estrogen in their bodies, albeit in different quantities. Sex hormones are involved in sexual drive (or libido), and maintenance and repair of reproductive tissues. They are also involved in body growth, body tissue, body mass, and bone mass.

Women 

Estrogen is an entire class of hormones including estriol, estradiol and estrone. Estriol is primarily needed during pregnancy. Estradiol affects female characteristics, and gynecologic issues. Estrone is widespread through the body, and is generally the only estrogen hormone present after women reach menopause.

During menopause – which begins at an average age of 50 years old – women’s levels of estrogren decrease, and these levels are associated with a variety of overall health issues. Women can experience symptoms including depression, dryness of vaginal lining, “hot flashes”, and decreased sex drive.

In women, a substantial amount of research has shown that estrogen metabolism is strongly associated with hormone-related cancers such as breast cancer. Estrogen, via its binding to the estrogen receptor, plays an important role in breast cancer cell proliferation and tumor development.

Resveratrol and Menopause

Taking resveratrol has many beneficial effects for menopausal women, as it helps in alleviating menopausal symptoms and prevents some degenerative diseases. In one clinical trial, postmenopausal women received trans-resveratrol for six months experienced increased bone mineral content and bone density.

Other studies with resveratrol indicate that Resveratrol inhibits the activity of aromatase. This enzyme is found in high concentration in malignant breast tumors. In fact, Resveratrol inhibits the conversion of estrogen and decreases the synthesis of the aromatase enzyme, thus indicating that it may support the health of individuals concerned about breast cancer.

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Resveratrol, Sex Drive, and Sex Hormones in Men

The key to understanding the affects of Resveratrol on sex drive lies in the understanding of the sex hormones estrogen and testosterone. While testosterone hormones are associated with men, and estrogen with women, both men and women have levels of testosterone and estrogen in their bodies, albeit in different quantities.

Sex hormones are involved in sexual drive (or libido), and maintenance and repair of reproductive tissues. They are also involved in body growth, body tissue, body mass, and bone mass.

Testosterone in men is highest in their teenage years, and gradually decreases over time. What is not generally understood, is that an increase in estrogen can also occur over a man’s lifetime, which further contributes to a decrease in testosterone. This phase in a man’s life is sometimes referred to as “male menopause.”

Decreased levels of testosterone, and increased levels of estrogen, can lead to numerous problems including reduced muscle mass, decreased strength, increased body fat storage, fatigue, erectile dysfunction and, of course, reduced sex drive. These hormonal changes have also been linked to prostate cancer and heart disease.

Decreasing estrogen levels can lead directly to an increase in testosterone levels. Here’s where Resveratrol enters the picture. Resveratrol has been scientifically shown to act as an anti-estrogen (antagonist) lowering estrogen levels in men, and may even block excess testosterone from turning into estrogen. The result – improved muscle, mass, strength, less body fat, and of course an increase in sex drive.

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From Wine Spectator Magazine:

Resveratrol Shows Anti-Viral Abilities

Italian study finds that the red-wine compound prevents viruses from replicating inside cells

Jacob Gaffney
Posted: September 30, 2009

Resveratrol, the polyphenolic compound found in red wine and the prominent focus of medical researchers, may be able to fight off viruses, according to a new Italian study. While the chemical has shown hints of anti-viral properties in previous studies, the new work shows that it appears to prevent virus replication at the cellular level. More research is needed to see how widespread the effect is.

Viruses, from the common cold to polio and the H1N1 “swine flu,” are infectious agents that can only reproduce inside the cells of a host, inserting their genetic material into the cells. The new study, published in the July issue of the Journal of Experimental & Clinical Cancer Research, finds that the polyomavirus is unable to hijack a cell for this purpose if resveratrol is around.

READ entire article

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ARTICLE Published in Life After 50 Magazine:

The All-Natural Supplement that May Prevent Killer Diseases

All About Resveratrol

By Mark Juliano

Thanks to stories on 60 Minutes, Oprah, Dr. Oz, and Barbara Walters, supplements based on Resveratrol now top the “hot list.”  Multiple studies conducted on laboratory animals have demonstrated the highly beneficial effects of this polyphenol (a class of plant chemicals) which is found in the skins of grapes and in red wine.

KEY ANIMAL FINDINGS

Resveratrol has been shown to enhance muscle strength, reduce fatigue, and help prevent heart disease, stroke, diabetes, and cancer.  It can help clear away the toxic proteins that cause Alzheimer’s disease, and even increase animals’ life span by 25-50%.  But can this substance do the same for humans?

AN IMPORTANT DISCOVERY

Resveratrol’s emergence as an anti-aging powerhouse began in the 1930s with the finding that calorie restriction – 30% less than a normal diet – could extend lifespan by 20-50% in both animals and humans.  In the 1990s, researchers at Harvard Medical School discovered that near starvation triggers an activation of “survival” or SIRT genes which produce enzymes that slow cellular aging.  The scientists also found that Resveratrol is the most powerful SIRT activator, especially in combination with other grape polyphenols, such as Quercetin.

CURRENT EVIDENCE

The most startling research result was found in 2003 at Harvard.  When given Resveratrol, obese mice lived as long as normal weight mice, and did not fall prey to diabetes, heart disease and other conditions.  Resveratrol appears to achieve these results through a number of mechanisms including a reduction in the inflammation which contributes to cardiovascular disease.

BREAKTHROUGH RESEARCH

A recent human study showed that drinking one and a half glasses of red wine per day reduced levels of lipid peroxide, a by-product of inflammation that damages arteries, by 40%.  At the same time, Resveratrol was shown to spark the production of the beneficial gas, nitric oxide, which increases blood vessel flexibility.  Resveratrol also thins the blood, reducing the risk for clots.

Cancer: Eighteen different types of cancer have been markedly inhibited in laboratory studies of human and animal cells.

Diabetes: Resveratrol helps normalize blood sugar levels by moving glucose out of the bloodstream and into cells, and stimulating natural insulin production.

Alzheimer’s: Resveratrol helps remove the amyloid-beta protein that causes brain damage associated with Alzheimers’s.

New Findings: In a study of 90 healthy adults, researchers at Marywood University found that a blend of 400mg of Resveratrol plus other polyphenols improved memory and sped up reaction time.

BEST SOURCES

To achieve an optimum dosage of 400mg of Resveratrol, one could consume massive quantities of grapes, red wine, or chocolate.  However, unhealthful quantities of calories, sugar, or alcohol would come along for the ride.  Look for a supplement blend with 98% pure Resveratrol extracted from the roots of polygonum cuspidatum – the Japanese Knotweed.  Ideally, Resveratrol is most effective when blended with the broad spectrum of polyphenols found in red wine grapes, and Quercetin, another powerful SIRT gene activator.

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 Scientific studies in both animals and humans have shown that a high Resveratrol dosage is required to activate sirtuins. A daily dosage of 300–500 mg is recommended from these studies.

Dr. James Smoliga studied humans in 2006, with a dosage of 400 mg of Resveratrol along with Red Wine grape extracts and Quercetin. His studies showed a marked improvement in strength, memory, and endurance – with no side-effects.

In 2002, the National Institute of Environmental Health Sciences commissioned a report, “Trans-resveratrol Review of Toxicological Literature.”  A review of more than 200 referenced scientific studies showed that there were no reported adverse effects from Resveratrol on humans. Massive dosage studies were also performed on animals. “The no observed adverse affect level (NOAEL) was 300 mg/kg/day,” which would be a human equivalent dosage of 30,000 mg or 10–100 times the concentrations contained Vindure 900.

900 mg of Active Polyphenol ingredients

Resveratrol alone also does not remain in the blood stream long enough to provide adequate contact with human cells. Rather, human studies have shown that the combination of red wine grape polyphenols (Resveratrol, Quercetin, Catechin, etc.) are the key to providing the medicinal benefits. That’s why Vindure 900 contains a highly-concentrated blend all red wine grape polyphenols, and enhances its formulation with extra Resveratrol and Quercetin.

400 mg Resveratrol

A significant dosage of Resveratrol is required to provide the health effects shown in many scientific studies.

400 mg whole grape Bordeaux extract

The Vinomis Red Wine Grape Extract ™ uses whole grapes, which provide all the compounds and health benefits of grape seeds, grape skins, and grape pulp.

100 mg Quercetin

Quercetin and other polyphenols have been scientifically shown to interact with Resveratrol to increase bioavailability.

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An extensive White Paper on Resveratrol, Red Wine Grapes, and Polyphenols has been published by Mark Juliano, President of Vinomis Laboratories. The 15-page white paper covers a broad range of related topics. CLICK HERE to read entire White Paper.

Resveratrol and Red Wine Grape Polyphenols: 

Nature’s Longevity and Healing Compounds  

Table of Contents 

Calorie Restriction and Longevity

Resveratrol Dosage

Types of Resveratrol Supplements

Recommendations for Supplements  

Resveratrol Safety

Human Clinical Trials

Consumer Testimonials 

WHITE PAPER EXCERPT: CLICK HERE to read entire White Paper

Age eventually conquers all.  As our bodies age, we undergo a significant transformation in cell structure, bone and muscle mass, hormones, immunities, and cognitive abilities.  This deterioration is compounded by cumulative stress, and the potential for heart disease, diabetes, neurological disorders such as Alzheimer’s, and cancer.  All in all, it is not a pretty picture. 

Yet, some people do age better than others, and live long healthy lives.  A growing number of people are living into their nineties and even past the century mark.  While  heredity and DNA markers surely contribute to our eventual lifespan, scientists have proven over decades of research that in addition to exercise and mental activity, diet and nutraceutical supplementation can not only prolong life, but can also allow us to lead healthier lives.  Proof that people have accepted these discoveries is evidenced by the explosive growth in health foods, organic foods, and nutritional supplements. 

Medical science has grown exponentially since the early 1900s.  During that same period, the average lifespan of humans has increased an average of 3 months each year, or a total of 30 years! Current advancements in nutrition have spawned a large nutraceutical supplement industry, and ingredients such as Resveratrol, Quercetin, and red wine grape polyphenols may be key ingredients to continued advancements in longevity research leading people to live longer, and live longer healthier.

About the Author:

Mark Juliano is an Adjunct Professor at Carnegie Mellon University, and President, CEO, and Founder of Vinomis Laboratories, a nutraceutical company that manufactures supplements based on Resveratrol, Quercetin and Red Wine Grape extracts.  He holds a BSE from Princeton, and an MBA from Stanford, and has authored numerous scientific and technical papers. 

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Unique Polyphenol Combination

Resveratrol + Red Wine Grape extracts + Polyphenols

Most other supplements other than Vindure 900, only include Resveratrol. While indeed Resveratrol has shown many positive health benefits, it should be remembered that the Harvard Medical School research identified seventeen (17) sirtuin-activating compounds found in red wine grapes. It is this combination of all of these polyphenols that nature produces to provide health benefits in humans.

Resveratrol + Quercetin = Bioavailability

It has been scientifically proven that the combination of Resveratrol and Quercetin (which has its own medicinal benefits) increase the bioavailability of Resveratrol in the blood stream, and maximize contact with the body’s cells.

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Decades ago, scientists discovered the French Paradox, and determined that despite a high fat diet, the French lived longer and healthier, and have concluded that the reason is their daily dose of red wine.

Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006 have shown that there are natural plant extracts that can activate survival genes and mimic the longevity effects of calorie restriction, without having to dramatically restrict calorie intake.

After investigating over 20,000 compounds, 19 of these compounds were identified, and 17, all polyphenols with strong antioxidant properties, are found in red wine grapes, including Resveratrol and Quercetin. Further, these polyphenols work together, and enable one another to stay longer in the blood stream – termed bioavailability.

Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet.

Even more impressive is that 1) they lived healthier lives by the prevention and delay of age-related diseases, and 2) even obese animals, who typically have age-related complications, lived normal-aged lives.

Health Benefits

Among the benefits discovered scientific research are:

• Powerful antioxidant
• Anti-inflammatory,
• Blood thinner and anti-coagulant (reduces risk for artery clotting)
• Normalization of blood sugar (for diabetes),
• Increase mental capacity and memory,
• Increase in strength and endurance,
• Removal of amyloid-beta proteins that may cause Alzheimer’s, and
• (even an) Inhibitor of many types of cancers (lung, colon, skin, liver and pancreatic).

Can it really be that all of these age-related issues may be dealt with using simply plant polyphenols compounds? Quite possibly, the answer is yes.

Exclusive Harvard Medical School patent

Vinomis has an exclusive Harvard Medical School license for proprietary science and has formulated its products using these principals. Harvard scientists found that when certain plants are put into a stressed xenohormetic environment (dehydration, infection, heat, cold, extreme UV exposure, etc.) they produce concentrated polyphenols such as Resveratrol and Quercetin. Many grapes are grown under these stressed conditions.

Marywood University study on Vindure 900 combination

In 2006, Xenomis, LLC. conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation:

• 400 mg of 98% pure Resveratrol
• 400 mg Red Wine Grape extract
• 100 mg Quercetin

This is the identical combination of ingredients found in Vindure 900.

The Smoliga study showed significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of pure red wine grape extract.

Naturex French study

Vinomis Red Wine Grape Extract™ uses whole grape extract from Naturex, called PowerGrape. In a study in 2005, a collaboration between researchers from Avantage Nutrition and the French Agronomic Research Institute (INRA), athletes were given 400 mg of Naturex Bordeaux extract per day. Results indicated a reduction in the risk of muscular damage, improvement in sports performance, improved recovery capacity, and improved antioxidant status.

Powerful Antioxidant

Brunswick Laboratories, the leader in antioxidant testing of foods and supplements, has determined that each Vindure 900 tablet from Vinomis Laboratories has an ORAC rating of 19,638, over six times times the USDA recommended daily consumption of at least 3000 ORAC units.

Other Scientific Studies

Grape extract reduces heart disease risk. In 2006, researchers at UC Davis assessed the effect of red grape extract on metabolic syndrome, a combination of factors that increase the risk for heart disease, including high blood pressure, excess abdominal body weight, high blood cholesterol fats and high blood sugar. A study at the University of Wisconsin of 15 adults with coronary artery disease discovered that the flavenoids (types of polyphenols) in red grapes may prevent cardiovascular events.

Resveratrol may block colon cancer. The Cancer Center at UC Irvine, followed up on previous in vitro studies showing that Resveratrol blocks a cellular signaling pathway known as the WNT pathway, which has been linked to more than 85 percent of sporadic colon cancers – the most common form of colon cancer.

Beneficial Effects of Quercetin. At the University of Western Australia, in Perth, a study using 200mg of Quercetin found that dietary flavonoids may improve endothelial function and ultimately lead to beneficial cardiovascular effects.

Grape extract increases energy production in cells – In 2006, athletes in Belgium was given 400 mg of Bordeaux red grape extract per day. Results included a 14% increase in lipophile antioxidant capacity, and a 96% increase in an antioxidant involved in energy production in cells.

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