Resveratrol Dosage Facts and Information
There is a lot of Internet chatter and false information being spread about Resveratrol dosage, claiming that a high dosage is “bad” for you. This is simply not true, and false information.
There are numerous human clinical trials, and studies by the National Institute of Environmental Health, and even animal studies to prove it. Of course, companies that sell a low-dosage ( 50 – 200 mg of Resveratrol) — will try to convince you otherwise. Those companies will tell you that you either don’t need more quantity. They may even tell you that their resveratrol is “more potent”. This just doesn’t make sense.
In 2002, the National Institute of Environmental Health Sciences commissioned a report entitled, “Trans-resveratrol Review of Toxicological Literature.” A review of more than 200 referenced scientific studies were included, and the report stated that there were no reported adverse effects from Resveratrol on humans.
Animal studies have used the human-equivalent of over 1,000 mg (10 mg/kg of bodyweight) of Resveratrol, and have shown no toxic effects. Massive dosage studies were also performed on animals. “The no observed adverse affect level (NOAEL) was 300 mg/kg/day,” which would be a human equivalent dosage of 30,000 mg or 10 – 100 times the maximum concentrations contained in human high-concentration oral nutraceutical dosages, such as in Vinomis’ Vindure 900 and others.
Human studies also confirm the safety and effectiveness of Resveratrol in highly concentrated forms. Studies including those at Marywood University, University of Leicester (UK) and University of Michigan, etc. all found no significant side effects and no evidence of toxicity
In 2006, Xenomis conducted a study on humans with Dr. James Smoliga of Marywood University (2006) using the formulation:
- 400 mg of 98% pure Resveratrol
- 400 mg Red Wine Grape extract
- 100 mg Quercetin
The Smoliga study showed no side-effects, and significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of Naturex red-wine grape extract.
World Renowned Professors Speak
We recently posed this question of Resveratrol Dosage to two(2) world-renowned Professors at Marywood University and the University of Pennsylvania who have been doing research on Resveratrol for over 7 years. Here are their email responses.
“I beleve there are one or two articles examining the pharmacokinetics of it [dosage] (combined with safety) which found it to be safe in up to 5g [5,000 mg] doses, I believe. It appears that with dosages in the 400 mg range, it reaches a peak and then subsides, whereas in the 1g (1,000 mg) or more range, higher blood concentrations are maintained. However, I believe it is not yet certain whether which would be more advantageous – to have a rise in fall in resveratrol concentration or a steady level of resveratrol. Based on some of the physiology, I would think a rise and fall mechanism would actuallly be more beneficial, and if this is the case the 400mg dosage should work quite nicely.”
[Note that Vindure 900 contains 400 mg of trans-Resveratrol, and 400 mg of Red Wine Grape extract]
Dr. Baur:
“I have attached one of the clinical trials Dr. S mentioned. Sirtris also went up to 5g [5,000 mg] of their “SRT501″ formulation without any ill effects:”
“We used ~5-30 mg/kg in our mice, and Johan Auwerx used 200-400 mg/kg. If you subscribe to the “allometric scaling” by body surface area method, you divide by 12 to go from mouse to human, yielding ~150 mg or ~2g [2,000 mg] as the respective human-equivalent doses. But since other polyphenols may have an additive or synergistic effect, I think it’s quite likely that Vindure is delivering the effect of a 2g [2,000 mg] dose of pure resveratrol.”
***Whatever you buy, make sure to read the product Supplement Facts. It’s the only way to be sure what you’re getting. If you can’t find them on the company’s website, I sincerely recommend not buying that supplement. Here are the Vindure 900 Supplement Facts
Filed under: Announcements, News, resveratrol
This website was used by certain Lisa Wilkinson as endorsement to Resveratrol Natural Rejuvenation product. I ordered a Pure Resver but I think Pureresver is just a front and instead I was send a Resveratrol Natural Rejuvenation prodcut citing a contact number of 866-9898947 which is not contactable.
Please warn the rest of the customer not to believe the resveratrol trial for Free