New York Times article on Resveratrol

Near Term Prospects for Increased Longevity

NY Times: “In five or six or seven years,” said Christoph Westphal, Sirtris co-founder [Sirtis was bought by GlaxoSmithKline for $720 million], “there will be drugs that prolong longevity.” [H/T Michael Annisimov, Accelerating Future]

Why wait?

There’s 98% pure and natural Resveratrol available today. Pharmaceutical companies want you to wait until their drugs are ready, but you can purchase products like Vindure 900 from Vinomis Laboratories today. The ingredient dosages in these products have been proven in laboratory tests of humans and animals to have similar effects to those mentioned about the Sirtris product — blood sugar levels in diabetics, increased lifespan, cancer prevention, etc. all with no side effects.

Below is the rest of the article, and a LINK to it:

SRT-501, the company’s special formulation of resveratrol, is being tested against two cancers, multiple myeloma and colon cancer that has spread to the liver. A chemical mimic of resveratrol, known as SRT-2104, is in a Phase 2 trial for Type 2 diabetes, and in a Phase 1 trial in elderly patients. (Phase 1 trials test for safety, Phase 2 for efficacy.)

Dr. Gallagher said that unpublished tests in mice showed that another chemical mimic, SRT-1720, increased both health and lifespan; after two years, twice as many mice taking the drug were alive compared with the undosed animals. Resveratrol itself has not been shown to increase lifespan in normal mice, although it does so in obese mice, laboratory roundworms and flies.

Sirtris has so far been doubly fortunate. No severe side effects have yet emerged from the clinical trials. The company has also been lucky in having apparently picked the right horse, or at least a good one, in a fast-developing field. 

Sirtuins may not be the most important genes for longevity, Dr. Sinclair conceded at the conference, because the pathways controlled by the sirtuins, TOR and the others “all talk to each other, often by feedback loops.” 

Many theories of aging attribute senescence to the inexorable buildup of mutations in a person’s DNA. Dr. Sinclair said that in his view “aging can be reversed” because the DNA mutations did not directly cause aging.

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