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There are numerous human clinical trials, and studies by the National Institute of Environmental Health, and even animal studies to prove it. Of course, companies that sell a low-dosage  ( 50 – 200 mg of Resveratrol) — will try to convince you otherwise. Those companies will tell you that you either don’t need more quantity. They may even tell you that their resveratrol is “more potent”. This just doesn’t make sense.

In 2002, the National Institute of Environmental Health Sciences commissioned a report entitled, “Trans-resveratrol Review of Toxicological Literature.”  A review of more than 200 referenced scientific studies were included, and the report stated that there were no reported adverse effects from Resveratrol on humans.

Animal studies have used the human-equivalent of over 1,000 mg (10 mg/kg of bodyweight) of Resveratrol, and have shown no toxic effects. Massive dosage studies were also performed on animals. “The no observed adverse affect level (NOAEL) was 300 mg/kg/day,” which would be a human equivalent dosage of 30,000 mg or 10 – 100 times the maximum concentrations contained in human high-concentration oral nutraceutical dosages, such as in Vinomis’ Vindure 900 and others.

Human studies also confirm the safety and effectiveness of Resveratrol in highly concentrated forms. Studies including those at Marywood University, University of Leicester (UK) and University of Michigan, etc. all found no significant side effects and no evidence of toxicity

In 2006, Xenomis conducted a study on humans with Dr. James Smoliga of Marywood University (2006) using the formulation:

• 400 mg of 98% pure Resveratrol
• 400 mg Red Wine Grape extract
• 100 mg Quercetin

The Smoliga study showed no side-effects, and significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of Naturex red-wine grape extract.

World Renowned Professors Speak

We recently posed this question of Resveratrol Dosage to two(2) world-renowned Professors at Marywood University and the University of Pennsylvania who have been doing research on Resveratrol for over 7 years. Here are their email responses.

Dr. Smoliga:

“I beleve there are one or two articles examining the pharmacokinetics of it [dosage] (combined with safety) which found it to be safe in up to 5g [5,000 mg] doses, I believe.  It appears that with dosages in the 400 mg range, it reaches a peak and then subsides, whereas in the 1g (1,000 mg) or more range, higher blood concentrations are maintained.  However, I believe it is not yet certain whether which would be more advantageous – to have a rise in fall in resveratrol concentration or a steady level of resveratrol.  Based on some of the physiology, I would think a rise and fall mechanism would actuallly be more beneficial, and if this is the case the 400mg dosage should work quite nicely.”

[Note that Vindure 900 contains 400 mg of trans-Resveratrol, and 400 mg of Red Wine Grape extract]

Dr. Baur:

“I have attached one of the clinical trials Dr. S mentioned.  Sirtris also went up to 5g [5,000 mg] of their “SRT501″ formulation without any ill effects:”

http://www.drugs.com/clinical_trials/sirtris-announces-positive-results-proprietary-version-resveratrol-srt501-phase-1b-type-2-diabetes-3127.html

“We used ~5-30 mg/kg in our mice, and Johan Auwerx used 200-400 mg/kg.  If you subscribe to the “allometric scaling” by body surface area method, you divide by 12 to go from mouse to human, yielding ~150 mg or ~2g [2,000 mg] as the respective human-equivalent doses.  But since other polyphenols may have an additive or synergistic effect, I think it’s quite likely that Vindure is delivering the effect of a 2g [2,000 mg] dose of pure resveratrol.”

***Whatever you buy, make sure to read the product Supplement Facts. It’s the only way to be sure what you’re getting. If you can’t find them on the company’s website, I sincerely recommend not buying that supplement. Here are the Vindure 900 Supplement Facts

Vinomis Comments on Resveratrol Lawsuits by Oprah Winfrey and Dr. Mehmet Oz

Oprah Winfrey, Dr. Mehmet Oz, and their companies have filed a lawsuit against a long list of companies using thier names and images to market nutritional supplements based on Resveratrol and other nutraceutical ingredients. Vinomis Laboratories applauds this effort to shut down deceptive practices which hurt our entire industry.

Pittsburgh, PA (PRWEB) September 15, 2009 — It has come to the attention of Vinomis Laboratories that certain companies, not including Vinomis have been named in a lawsuit from Oprah Winfrey and Dr. Mehmet Oz concerning unauthorized and potentially illegal use of their names in the marketing and supposed endorsements of nutraceutical supplement products. Vinomis is not named in the lawsuit, and does not practice the kind of marketing techniques outlined in Ms. Winfrey’s and Dr. Oz’s lawsuit. (Case 1:09-cv-07297-DAB in the Southern District of New York)

“We applaud Ms. Winfrey and Dr. Oz for investigating and taking this action,” said Mark Juliano, President and CEO of Vinomis Laboratories. “These types of marketing activities tarnish the whole industry, and are delighted that Ms. Winfrey and Dr. Oz have decided to take strong action.”
Resveratrol, fish oils, Acai berries, and other nutraceuticals mentioned in the lawsuit do possess many positive health benefits. There is no need to use deceptive marketing tactics, as the products and scientific studies speak for themselves.

“Vinomis uses no celebrity endorsements in its marketing,” commented Barry Yarkoni, Marketing Vice President, “Our endorsements are from doctors, patients, researchers, and customers.”

Vinomis maintains a “co-compromise” approach to product quality, and complements this with honesty and openness in its marketing activities. For example, the quantity of Resveratrol in Vindure 900 is conservatively stated on the Supplement Facts label. While there is actually 428mg of polygonum cuspidatum extract, the product label lists only 400mg of pure trans-Resveratrol to compensate for the 98% purity, and allowing for a long shelf life.

The Vinomis Red Wine Extract contains over 90% polyphenols. Testing performed at Brunswick Laboratories, determined an ORAC value of 19,638 per tablet. The manufacturing plant where Vindure is produced is FDA, TGA, USP, and NSF certified. All the ingredients used in our products have been tested in human clinical trials.

The Vinomis website is accurate and straightforward. The home page, and other pages, list the precise ingredients contained in our products, and the full Supplement Facts label is available for viewing. Each web page contains contact information including the Vinomis toll-free phone number (877-484-6664) and email address (support@vinomis.com).
The founders of Vinomis Laboratories are doctors, university professors, and former executives of major Fortune 500 companies in the nutraceutical, consumer products, and technology industries.

Vindure is available through the company’s website at Vinomis.com, and through a network of retailers and medical professionals who are recommending Vindure to patients. Vindure 900 includes pure Resveratrol, Quercetin, and red wine grape extract from Bordeaux.

Vinomis Launches New Learning Center for Resveratrol, Red Wine Grape Extracts, Antioxidants and Polyphenols Information

Vinomis has added a Learning Center to educate the public on the latest scientific information about Resveratrol, Red Wine Grape extracts, Antioxidants, and Polyphenols.

Pittsburgh, PA (PRWEB) August 17, 2009 — Vinomis Laboratories, the leader in nutraceutical supplements based on Resveratrol, Quercetin, Red Wine grape extracts, and polyphenols has launched the Vinomis Learning Center.

This website provides comprehensive information about a broad range of subjects surrounding Resveratrol, polyphenols, antioxidants, and Red Wine grapes and extracts. Topics include basic science, scientific studies, medical benefits, foods, and dietary supplements. In addition, Vinomis has launched its FORUM where users can openly share thoughts, experiences, and advice on a broad range of medical topics.

Vinomis’ contributors include its founders, medical advisors, doctors, medical practitioners, and industry experts. Consumers and others are welcome to comment as it is written in a Blog format. The Learning Center is a moderated, SPAM-free website.

The FORUM is for anyone (the average person as well as medical practitioner), to share their thoughts, insights and experiences on related topics. Anyone can join, read and contribute.
The Learning Center can be accessed at www.vinomis.com/learning-center/. The consumer and user FORUM is located at www.vinomis.com/forum

“The marketplace and the Internet today are cluttered with biased information about Resveratrol, extracts and nutraceutical supplements,” said Barry Yarkoni, Vinomis vice president of marketing. “Our goal is to separate the wheat from the chaff and provide quality information to consumers and medical professionals.”

“It may be trite to say, but an educated consumer is our best customer,” said Mark Juliano, Vinomis President and CEO. “Vinomis is dedicated to providing accurate and timely information to the industry, consistent with our medical and scientific principles. Our goal is to be the leader both in products and product, medical and industry information.”

There are currently over 100 pages of information in the Learning Center and related web pages, and 1,000s of links among pages, and to a host of other websites, articles, blogs, etc. on the Internet.

Among the current topics included in the Learning Center are 1) Resveratrol, 2) aging, 3) foods and drinks, 4) medical benefits, 5) science, 6) Resveratrol dosage, 7) fitness and athletics, and product information on available Resveratrol and Red Wine grape extract supplements. The Learning Center is updated daily as new industry and product information becomes available.

Vinomis Laboratories develops and distributes nutraceutical products based upon new science from an exclusive Harvard Medical School license. Their products are formulated to provide the benefits of red wine polyphenols, including Resveratrol and Quercetin, in the highest quality products.

• Some doctors are doing blood work for their customers
• We have called select customers at their request
• Doing surveys

We all know the long-term benefits of Resveratrol, Quercetin, and Red Wine grape extracts, but we’re also getting a number of short-term results:

Here are the results so far:

Many (>50%) customers report the following (these are all related)

• Increased energy level (80%+)
• Improved mental clarity
• Improved mood level (elimination of depression in some cases)
• Lower appetite and weight loss

Also reporting:

• Moderation and/or lower of blood sugar levels
• Lowering of cholesterol levels
• Increased urination on patient with prostrate issues (this is a good thing)

Any side effects?

• Some report less sleep due to energy levels. This effect is eliminated if patients take Vindure 900 in the morning
• Very few have reported diarrhea (this is possible with many medications or supplements)
• Recommend taking Vindure 900 with food

• ask questions
• talk about Resveratrol, red wine extracts, quercetin, polyphenols, etc.
• talk about diseases and illnesses
• converse with others like you
• state your Vindure 900 stories & experiences
• voice your opinions
• get feedback from other Vindure 900 users
• etc.

Go to www.vinomis.com/forum or click on the Forum links on the Vinomis website

July 21, 2009  Pittsburgh, PA – Brunswick Laboratories, the leader in antioxidant testing of foods and supplements, has determined that each Vindure 900 tablet from Vinomis Laboratories has an ORAC rating of 19,638, over six times times the USDA recommended daily consumption of at least 3000 ORAC units.  A copy of the Brunswick report is posted on the Vinomis website.

Antioxidants are chemicals which “scavenge” free oxygen radicals from the body, preventing cell damage from oxidation.  Health problems such as heart disease, macular degeneration, strokes, Alzheimer’s, diabetes, cancer etc. are all contributed to by oxidative damage from free radicals.  According to Dr. Bryan Donohue, chief of cardiology at UPMC, “Our bodies produce free oxygen radicals as a natural by-product of energy production in cells.  However, as we age, the mechanisms for neutralizing them decrease.  The excess free radicals cause cellular damage, and by reacting with cholesterol in the bloodstream, form deposits that can clog arteries.”

According to Jeff Bost PAC, author of “Fish Oils – The Natural Anti-Inflammatory,” and Clinical Instructor in Neurological Surgery at UPMC, “the increasing level of environmental toxins, and a long-term decline in the antioxidants found in our foods, make antioxidant supplements a vital component of good health.”

Dr. Mehmet Oz, on the “Oprah” website, demonstrates antioxidant power by comparing apples to apples—one half of an apple is sprinkled with lemon juice and the other is not.  While the lemony half remains new and crisp-looking, the untreated half becomes brown and shriveled because of exposure to oxygen, also called oxidation.  ”The same thing happens to our skin, to our heart, to our eyes,” Dr. Oz says.  ”All of our bodies need to have the antioxidants.”

The antioxidant power of Vindure comes from a hefty dose of its three primary ingredients: over 400mg of 98% pure trans-Resveratrol, 100mg of pure Quercetin, and 400mg of red wine grape extract containing over 90% polyphenols.  According to Mark Juliano, Vinomis CEO, “The Resveratrol, Quercetin, and other Polyphenols in Vindure provide a double benefit – they are super-powerful antioxidants, as well as SIRT gene activators.”

In 2003, a team of scientists at Harvard Medical School discovered that 19 polyphenols, of which 17 are found in red wine grapes, activate the SIRT genes, causing them to produce enzymes call Sirtuins that are a critical component in slowing down the aging process.  Resveratrol was found to be the number one activator of these genes.  Every 100mg of pure Resveratrol has the added benefit of adding over 3000 ORAC units of antioxidants, to our diet.

Antioxidants have received a lot of attention from promoters of “super-fruit” products, containing Acai, Blueberry, Mangosteen, Noni, and Pomegranate.   But it turns out that each Vindure tablet, containing over 860mg of pure polyphenols including 400mg of whole Bordeaux grape extract, exceeds the antioxidant power found in an average serving of ANY of the so-called “superfruits.”

The relationship between antioxidants and various health issues has been well established.  According to the National Cancer Institute, “Considerable laboratory evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow or possibly prevent the development of cancer.”  The American Academy of Family Physicians recommends supplementation with antioxidants (except beta carotene) to prevent coronary heart disease, reporting that, “… studies find lower coronary heart disease morbidity and mortality in persons who consume larger quantities of antioxidants in foods or supplements.”

Vinomis Laboratories develops and distributes nutraceutical products based upon new science from an exclusive Harvard Medical School license.  Their products are formulated to provide the benefits of red wine polyphenols, including Resveratrol and Quercetin, in the highest quality products.

Contact:

Barry Yarkoni
VP Marketing
Vinomis Laboratories, LLC
www.Vinomis.com
323-282-7224
BarryY@Vinomis.com

Affiliates will be able to earn cash from their sales, or Free Vindure 900 bottles. Earn $100s per month, $1000s per year.

CLICK HERE to LEARN more about the Affiliate Program

Selling Vindure 900 is a no-pressure situation where you tell your friends your experiences. Vinomis will provide you with a “VAP Kit” complete with products, brochures, sample packs, literature and a presentation.

If you’re interested in the VAP program, email us at info@vinomis.com or call 1-877-484-6664

Stay tuned for more information …

Find out what it’s like to envision, create, and bring to market a real, high quality nutraceutical product.

Check it out.

http://www.vinomis.com/resveratrollife

or

http://www.vinomis.com/startuplife