It’s well known that as we age, our ability to respond to insulin worsens.  When insulin can’t get into the cells to allow sugar in, the blood sugar level starts rising and does damage to every organ.  This is called insulin resistance.

Crandall has had a long history of researching diabetes.  She’s examined the genetic aspects of diabetes and prevention programs for diabetics, and studied treatments and complications of the disease.  In this recent study, she found that Resveratrol makes the cells more sensitive towards insulin, thereby decreasing insulin resistance.  Volunteers tested were older people with mild insulin resistance with an average age of 72.

No one wants to get diabetes as they age; the disease is a major killer.  With diabetes, one can expect several different organs to fail in due time – the heart, blood vessels, kidneys, immune system, and eyes.  It’s no fun to not have endurance and stamina, live at the dialysis clinic, be susceptible to every bug going around the neighborhood, and risk vision loss.  Saving lives from disease and consequent discouragement, frustration and strife is more than a noble deed reserved for researchers; it’s a responsibility that each one of us should take on.

Crandall found that Resveratrol was helpful in reversing insulin resistance with the caveat that these are preliminary research study results.  However, as more and more of these studies are completed, the case for Resveratrol’s effects on insulin sensitivity becomes more compelling.

As you may already know, current medical opinion is that aspirin inhibits blood clots and reduces the risk of death from heart attack and stroke. Aspirin benefits a lot of people with coronary artery disease and atherosclerosis or hardening of the arteries. It’s prescribed to those who have had a heart attack.

Aspirin works by preventing blood platelets from clumping together to form a blood clot. This process is regulated by chemicals that are known as prostaglandins. Just like you have good cholesterol and bad cholesterol or good carbs and bad carbs, you also have good prostaglandins and bad prostaglandins in the body. The good prostaglandins keep inflammation and clotting to a minimum. The bad prostaglandins trigger events that cause clotting and inflammation. Aspirin keeps the blood free-flowing, thus reducing the risk of clots.

Hungarian researchers found that high-risk cardiovascular patients can still suffer a serious vascular event (heart attack or stroke) even though they are on aspirin. The aspirin fails to stop the platelets from clumping together to form the clot in 1 out of every 5 incidents related to heart disease for this high risk group of people.

Now imagine if you are a patient with heart disease. How would you know if you are in that 20% or not? There’s no way that your friendly clinical laboratory or doctor’s office will be able to predict this. However, in research, this is measured by platelet clumping found in the blood after epinephrine or collagen is added to the blood of a person taking aspirin.

How could people predict dying from a heart attack or stroke if they were in the aspirin failure group? That thought was enough to stimulate researchers to try to solve the problem. They knew that Resveratrol had the ability to inhibit platelet clumping (aggregation) in animals. They decided to test it in humans. Those that had the highest aggregation rate were also high on the scale for aspirin failure.

And here’s the part where Resveratrol came to the rescue. Researchers found that they could influence what was happening by adding Resveratrol to the diet. Resveratrol worked best in the cases where the platelet clumping from collagen and epinephrine were at a maximal level; i.e., those who were aspirin resistant. Researchers concluded that the heart-protective effects of Resveratrol could be due to this blood clot preventative activity.

As someone with a family history of heart disease, I’m glad that Vinomis has done all the work necessary to create a great Resveratrol supplement. The Vindure 900 contains more Resveratrol than any other company on the market.

Here’s why.  Respiratory diseases are often accompanied by inflammation of the airways caused by allergens and viruses. Sometimes even a high count of mold in the home can cause an asthma attack. In COPD, smelling the smoke of one cigarette could be enough of a trigger to start the inflammation process. The problem with inflammation is that it doesn’t stop there. Inflammation activates immune system responses on multiple levels and causes free radicals to be produced in massive quantities. When this happens, it’s called oxidative stress in the body.

There is something that can prevent oxidative stress from becoming very damaging to the body and especially in this case, the lungs. It’s antioxidants, the free radical quenchers in the body.

You’re already familiar with the antioxidants, vitamin A, vitamin C and vitamin E. But did you know that Resveratrol also acts as an antioxidant in the body? This is great news, but there’s more. Resveratrol also acts as an anti-inflammatory agent.

When you have asthma or COPD, taking something that is both an antioxidant and an anti-inflammatory agent could potentially help a lot.

Resveratrol is the buzz among scientists who study respiratory disease for this reason. If you want to find out more, you’ll have to take a trip to your closest medical library to find the journal Antioxidant Redox Signal. Look for the March 9, 2010 issue and the article called Antioxidant and Anti-Inflammatory Effects of Resveratrol in Airway Disease. The researchers included all the evidence that shows that Resveratrol protects the lungs in those with lung disease. If you are a Resveratrol advocate and love to read the science reports, you’ll love how the authors detail exactly how Resveratrol acts in the lungs.

The opposite of insulin resistance is insulin sensitivity.  This is where the cells are surrounded by plenty of insulin and even when very small amounts of insulin are nearby, the cells let it in to bring the sugar to them to be used as fuel. This situation could be considered comparable to a child, hungry for ice cream. While the child is playing in the back yard or in the basement, he hears the music of the Ice Cream Man’s truck a few blocks away. His mother says, “Get your allowance, honey! The Ice Cream Man is on his way!” The child is sensitive to the sound of the ice cream man (insulin) and his mother (the cells) allow the ice cream to be purchased.

Chinese researchers found that Resveratrol improves the body’s ability to be more insulin sensitive.  That’s a good thing.

They found that Resveratrol worked best in fat cells to do this, and made those fat cells more insulin sensitive by turning off genes that made the fat cells insulin resistant. Resveratrol also worked by affecting hormone-signaling systems that control insulin resistance and insulin sensitivity.

This is great news for diabetics. For a long time, we’ve known that Resveratrol can make a significant difference in animals with diabetes. But it doesn’t mean that diabetics can return to eating a diet of fried food, sugary desserts and high carbohydrate meals. Some things will never change…

This research, published in the journal called Biochimie in late February 2010 adds even more evidence to the list of positive benefits experienced by Resveratrol.

What would happen to the incidence of diabetes in America if every diabetic took Vindure 900? It’s something to think about.

Other scientists have been curious about the effects of Resveratrol on the rest of the GI tract, not just on ulcers.

Grapes are squeezed under pressure to get the grape juice out.  The substances that remains are all the solid materials found in the grape.  This remaining material is called pomace.  It’s the same with any other fruit or vegetable.  For example, when olives are pressed the old fashioned way with an 8 to 10-foot diameter flat stone that revolves around a fulcrum, the golden olive oil is collected, leaving the pomace. That pomace, no matter if it’s from grapes, olives or other fruits and vegetables, is full of polyphenols and plant constituents, many which may be beneficial to one’s health.

In a study coming out of Madrid, Spain, the country with the greatest number of acres of vineyards, scientists took that grape pomace which is rich in dietary fiber and polyphenols and investigated how it interacted with the flora in the colon.

Many dietary polyphenols are not absorbed in the small intestine but they interact with microbes in the colon.  The big question was what do polyphenols do to the growth of Lactobacillus Acidophilus?

Lactobacillus Acidophilus is one of the primary types of bacteria found in the GI system.  It’s there for us to synthesize vitamins and help balance the pH.  It feeds the tissues of the colon and keeps pathogenic bacteria in check.  Without enough Lactobacillus bacteria in the colon, there’s more of a tendency to become prone to GI illnesses.  In the field of alternative healing and complementary medicine, probiotic supplements that are taken can calm down quite a few GI system upsets so practitioners frequently recommend them.  These often contain Lactobacillus as the primary strain of bacteria.

Scientists found that grape polyphenols stimulated the production of Lactobacillus Acidophilus in test tube experiments.

If this same effect works inside human GI systems, it’s a great thing.  It could mean that the grape polyphenols might be enough of a pre-biotic for the colon and that Lactobacillus probiotic capsules may not need to be taken, or taken at a lower dose.  Only time will tell. In the meantime, I’ll continue taking my Vindure 900.

Back in 2005, Japanese scientists discovered that proanthocyanidin, a polyphenol from grape seed, inhibited a clot that normally formed in the carotid artery from laser irradiation.  It didn’t matter whether or not that polyphenol was given by mouth or administered intravenously to the mice in the study.  This was the first evidence that grape polyphenols could help prevent heart disease.

Recently at the end of 2009, Tokyo scientists at the Department of Food Technology at the Nagano Prefecture General Industrial Technology Center found polyphenols, anthocyanidins (five total) and Resveratrol in the skins of Nagano purple grapes.  They gave the polyphenols to the human volunteers in their study and one hour later, checked their cholesterol level to look for something called oxidation.  The process of oxidation is where free radicals are being formed on the LDL molecule, so to speak. It’s a bad sign when this happens because these damaged LDL molecules will further damage the arteries.

The scientists found that the polyphenols in the grape gave protection against LDL oxidation and that’s great news for those prone to heart disease. It means that Resveratrol could potentially protect other people from heart disease; blood vessel damage.

I don’t know if you really understand the impact of this in someone’s life, but if someone in your family dies at an early age from heart disease, it is very difficult for the family to go on.  My own dad passed away at the age of 48 years old from a massive heart attack when I was only 19 years old.  I really missed him and found that it seriously affected my life by not having him around.  I needed a father in my life, as every young woman or young man does.

With Resveratrol, I believe that potentially a lot of families can be saved from the ravages of heart attacks that kill … and ruin a family.

I’m excited about all this new Resveratrol research and what Vinomis is providing with their Resveratrol and Grape Polyphenols and Quercetin.  I look at Vinomis in such a positive way – essentially a family saver!

And every time I look at the Vindure 900 tablet sitting on the breakfast table with my other nutritional supplements, I think about Polyphenol Power!

Resveratrol is a non-flavonoid polyphenol found in grapes and Japanese knotweed.

As you already know, Vindure 900 is a superior product on the market because it not only contains Resveratrol, but also the polyphenol, Quercetin, and additional polyphenols found in grapes.

When Quercetin is added to Resveratrol, the Resveratrol stays in the blood longer, potentially benefiting the person or animal for a longer period of time. The additional polyphenols found in grapes may also extend the time and / or benefits of Resveratrol.

This makes a lot of sense because plant chemicals in foods often enhance each other. A potentially beneficial constituent could have its biological activity enhanced by three other constituents in that same plant.

Since 2006, researchers reported on other chemicals, melatonin and serotonin, found in grapes.

Grapes contain melatonin and serotonin?

Yes, that’s right!

These other chemicals could change how doctors eventually treat their patients.  For example, if someone is having difficulty adjusting sleep cycles because of international travel, maybe grape polyphenols along with Resveratrol could be part of the solution.  If someone is not responding well to anti-depressant medication, perhaps grape polyphenols and Resveratrol would be an adjunct treatment.

Nobody seems to know what the relationship of melatonin and serotonin is to Resveratrol or Quercetin or the other polyphenols at this time but one thing is certain–they all work together to enhance health and longevity.

But what exactly is a grape polyphenol?

Polyphenols are chemical substances found in plants that have more than one phenol group on them. There are hundreds of types of polyphenols found in plants of all types, including grapes.  The polyphenols are responsible for how foods taste, their color, and how they feel in your mouth.  They are water soluble.

Grape and plant polyphenols can be divided into two categories – flavonoids and non-flavonoids.  Some of the flavonoids found in grapes are similar to the bioflavonoids found in the yellow part of the rind of oranges and grapefruit. In grapes, sun exposure increases the concentration of flavonoids.  These compounds include anthocyanins and tannins.  Anthocyanins are responsible for grapes to turn color when ripe.  Tannins are chemical compounds that are astringent, or make your mouth pucker.  In red wine, flavonoids make up about 90% of the polyphenolic compounds.

One flavonoid found in grapes is Quercetin, which is a component of Vindure 900.  Others include ellagic acid, kaempferol, and myricetin.

Resveratrol is one of the non-flavonoid compounds.

When grapes are made into wine, the skin of the grape increases the amount of polyphenols in the wine.  Red wine has a greater amount of polyphenols than white wine because white wine does not have contact with the skin of the grape.  Aging wine in oak barrels increases the polyphenol content by increasing a phenol called vanillin.  Vanillin gives these wines a vanilla aroma.

Vinomis wants you to have all the polyphenol power you can get.  That’s why they include not only Resveratrol, but also Quercetin and grape polyphenols together in Vindure 900.  With this winning combination, you can only experience benefits.

The scientists love Resveratrol because it’s easy for them to see a difference in almost anything they test, whether it’s immune system status, LDL-cholesterol oxidation, cardiovascular risk, or anti-aging effects.

These scientists are from all around the world. Here’s a short list of some of the research labs around the world that are making history with their work:

• The Department of Pharmacology and Toxicology at the University of Alabama at Birmingham, Alabama discovered that Resveratrol suppressed prostate cancer in rats.

• The Department of Anesthesiology at Chang Gung University in Taiwan found that rats with liver injury and hemorrhage were significantly helped with Resveratrol.

• At the School of Medicine in Aix-Marseille University in France, Resveratrol was taken in by thyroid cells in a process called iodide trapping and was found to be a promising molecule for radioiodide therapy in thyroid cancer patients.

• At the Department of Pharmacology at Johannes Gutenberg University in Mainz, Germany, Resveratrol was found to help boost production of enzymes necessary for detoxification of the body (superoxide dismutase and glutathione peroxidase 1).  These scientists concluded that because of this action, the Resveratrol would protect the blood vessels.

• At the University of Iowa in the Department of Internal Medicine at Carver College of Medicine, scientists used a rat model to see if they could impact Parkinson’s disease with Resveratrol’s antioxidant and anti-inflammatory actions.  The part of the brain destroyed by this neurological disease was protected with Resveratrol.

• And at the Department of Gastroenterology and Hematology at the Graduate School of Medicine and Pharmaceutical Sciences at the University of Toyama in Japan, Resveratrol blocked changes in the test tube cells induced by Helicobacter pylori (H. pylori).  This research confirmed Resveratrol’s anti-cancer and anti-inflammatory activity.

Scientists from Alabama, Iowa, Taiwan, Japan, Germany and France all agree – everyone should take a look at all the good things that Resveratrol is doing! And there’s more to come.

Have you taken your Vindure 900 today?