The opposite of insulin resistance is insulin sensitivity.  This is where the cells are surrounded by plenty of insulin and even when very small amounts of insulin are nearby, the cells let it in to bring the sugar to them to be used as fuel. This situation could be considered comparable to a child, hungry for ice cream. While the child is playing in the back yard or in the basement, he hears the music of the Ice Cream Man’s truck a few blocks away. His mother says, “Get your allowance, honey! The Ice Cream Man is on his way!” The child is sensitive to the sound of the ice cream man (insulin) and his mother (the cells) allow the ice cream to be purchased.

Chinese researchers found that Resveratrol improves the body’s ability to be more insulin sensitive.  That’s a good thing.

They found that Resveratrol worked best in fat cells to do this, and made those fat cells more insulin sensitive by turning off genes that made the fat cells insulin resistant. Resveratrol also worked by affecting hormone-signaling systems that control insulin resistance and insulin sensitivity.

This is great news for diabetics. For a long time, we’ve known that Resveratrol can make a significant difference in animals with diabetes. But it doesn’t mean that diabetics can return to eating a diet of fried food, sugary desserts and high carbohydrate meals. Some things will never change…

This research, published in the journal called Biochimie in late February 2010 adds even more evidence to the list of positive benefits experienced by Resveratrol.

What would happen to the incidence of diabetes in America if every diabetic took Vindure 900? It’s something to think about.

The scientists love Resveratrol because it’s easy for them to see a difference in almost anything they test, whether it’s immune system status, LDL-cholesterol oxidation, cardiovascular risk, or anti-aging effects.

These scientists are from all around the world. Here’s a short list of some of the research labs around the world that are making history with their work:

• The Department of Pharmacology and Toxicology at the University of Alabama at Birmingham, Alabama discovered that Resveratrol suppressed prostate cancer in rats.

• The Department of Anesthesiology at Chang Gung University in Taiwan found that rats with liver injury and hemorrhage were significantly helped with Resveratrol.

• At the School of Medicine in Aix-Marseille University in France, Resveratrol was taken in by thyroid cells in a process called iodide trapping and was found to be a promising molecule for radioiodide therapy in thyroid cancer patients.

• At the Department of Pharmacology at Johannes Gutenberg University in Mainz, Germany, Resveratrol was found to help boost production of enzymes necessary for detoxification of the body (superoxide dismutase and glutathione peroxidase 1).  These scientists concluded that because of this action, the Resveratrol would protect the blood vessels.

• At the University of Iowa in the Department of Internal Medicine at Carver College of Medicine, scientists used a rat model to see if they could impact Parkinson’s disease with Resveratrol’s antioxidant and anti-inflammatory actions.  The part of the brain destroyed by this neurological disease was protected with Resveratrol.

• And at the Department of Gastroenterology and Hematology at the Graduate School of Medicine and Pharmaceutical Sciences at the University of Toyama in Japan, Resveratrol blocked changes in the test tube cells induced by Helicobacter pylori (H. pylori).  This research confirmed Resveratrol’s anti-cancer and anti-inflammatory activity.

Scientists from Alabama, Iowa, Taiwan, Japan, Germany and France all agree – everyone should take a look at all the good things that Resveratrol is doing! And there’s more to come.

Have you taken your Vindure 900 today?

Although Glaxo is still years away from having an FDA approved drug for sale, Pfizer, a major Glaxo competitor, has begun the competitive battle, casting doubt on Glaxo’s claims.  Yet Pfizer’s own researcher, Dr. Kay Ahn was quoted in an article last month in Nature magazine, and downplayed the significance of her study.  “Under our conditions we didn’t see beneficial effects, but we don’t want to make a big conclusion out of those results,” she said.

Glaxo said in a statement that “scientific debate around the interpretation of data is a normal part of discovery in emerging areas of research.” It maintains that Pfizer’s interpretation of data “is at odds with multiple studies conducted at Sirtris and those published by independent investigators.” The company added that the “purity of the compounds that were used in their study … cannot be ascertained due to the lack of data provided. The publication also does not cite nor discuss multiple scientific publications which are in direct contrast to their primary conclusions; as such it is unclear how to place this work in perspective of what has been found by other investigators.”

Vinomis Laboratories, makers of the over-the-counter supplement Vindure 900, based on Resveratrol, Quercetin, and other red wine grape polyphenols, reports that their customers are reporting results consistent with the Resveratrol studies done at Harvard Medical School.  Says Barry Yarkoni, CEO, “whether the benefits are the result of Sirtuin activation will be the subject of much ongoing research.  However, the benefits that people are experiencing from our product are very real regardless of what scientists determine the exact mechanisms to be.”

For more information Resveratrol and Diabetes, CLICK HERE

EXCERPT:

(NaturalNews) Think of a treatment for diabetes, and you probably think of a drug or natural therapy that targets the pancreas to help normalize blood sugar levels. Resveratrol, a phytochemical found in red grapes, has been shown to have a host of health benefits — including improving diabetes in animal studies. But, it turns out, that’s not necessarily because it benefits the pancreas. Instead, scientists have made an unexpected discovery:resveratrol’s anti-diabetic properties appear to be mediated through the brain.

Read entire article: Click here

For more information Resveratrol and Diabetes, CLICK HERE

Women 

Estrogen is an entire class of hormones including estriol, estradiol and estrone. Estriol is primarily needed during pregnancy. Estradiol affects female characteristics, and gynecologic issues. Estrone is widespread through the body, and is generally the only estrogen hormone present after women reach menopause.

During menopause – which begins at an average age of 50 years old – women’s levels of estrogren decrease, and these levels are associated with a variety of overall health issues. Women can experience symptoms including depression, dryness of vaginal lining, “hot flashes”, and decreased sex drive.

In women, a substantial amount of research has shown that estrogen metabolism is strongly associated with hormone-related cancers such as breast cancer. Estrogen, via its binding to the estrogen receptor, plays an important role in breast cancer cell proliferation and tumor development.

Resveratrol and Menopause

Taking resveratrol has many beneficial effects for menopausal women, as it helps in alleviating menopausal symptoms and prevents some degenerative diseases. In one clinical trial, postmenopausal women received trans-resveratrol for six months experienced increased bone mineral content and bone density.

Other studies with resveratrol indicate that Resveratrol inhibits the activity of aromatase. This enzyme is found in high concentration in malignant breast tumors. In fact, Resveratrol inhibits the conversion of estrogen and decreases the synthesis of the aromatase enzyme, thus indicating that it may support the health of individuals concerned about breast cancer.

Dr. James Smoliga studied humans in 2006, with a dosage of 400 mg of Resveratrol along with Red Wine grape extracts and Quercetin. His studies showed a marked improvement in strength, memory, and endurance – with no side-effects.

In 2002, the National Institute of Environmental Health Sciences commissioned a report, “Trans-resveratrol Review of Toxicological Literature.”  A review of more than 200 referenced scientific studies showed that there were no reported adverse effects from Resveratrol on humans. Massive dosage studies were also performed on animals. “The no observed adverse affect level (NOAEL) was 300 mg/kg/day,” which would be a human equivalent dosage of 30,000 mg or 10–100 times the concentrations contained Vindure 900.

900 mg of Active Polyphenol ingredients

Resveratrol alone also does not remain in the blood stream long enough to provide adequate contact with human cells. Rather, human studies have shown that the combination of red wine grape polyphenols (Resveratrol, Quercetin, Catechin, etc.) are the key to providing the medicinal benefits. That’s why Vindure 900 contains a highly-concentrated blend all red wine grape polyphenols, and enhances its formulation with extra Resveratrol and Quercetin.

400 mg Resveratrol

A significant dosage of Resveratrol is required to provide the health effects shown in many scientific studies.

400 mg whole grape Bordeaux extract

The Vinomis Red Wine Grape Extract ™ uses whole grapes, which provide all the compounds and health benefits of grape seeds, grape skins, and grape pulp.

100 mg Quercetin

Quercetin and other polyphenols have been scientifically shown to interact with Resveratrol to increase bioavailability.

Resveratrol and Red Wine Grape Polyphenols: 

Nature’s Longevity and Healing Compounds  

Table of Contents 

Calorie Restriction and Longevity

Resveratrol Dosage

Types of Resveratrol Supplements

Recommendations for Supplements  

Resveratrol Safety

Human Clinical Trials

Consumer Testimonials 

WHITE PAPER EXCERPT: CLICK HERE to read entire White Paper

Age eventually conquers all.  As our bodies age, we undergo a significant transformation in cell structure, bone and muscle mass, hormones, immunities, and cognitive abilities.  This deterioration is compounded by cumulative stress, and the potential for heart disease, diabetes, neurological disorders such as Alzheimer’s, and cancer.  All in all, it is not a pretty picture. 

Yet, some people do age better than others, and live long healthy lives.  A growing number of people are living into their nineties and even past the century mark.  While  heredity and DNA markers surely contribute to our eventual lifespan, scientists have proven over decades of research that in addition to exercise and mental activity, diet and nutraceutical supplementation can not only prolong life, but can also allow us to lead healthier lives.  Proof that people have accepted these discoveries is evidenced by the explosive growth in health foods, organic foods, and nutritional supplements. 

Medical science has grown exponentially since the early 1900s.  During that same period, the average lifespan of humans has increased an average of 3 months each year, or a total of 30 years! Current advancements in nutrition have spawned a large nutraceutical supplement industry, and ingredients such as Resveratrol, Quercetin, and red wine grape polyphenols may be key ingredients to continued advancements in longevity research leading people to live longer, and live longer healthier.

About the Author:

Mark Juliano is an Adjunct Professor at Carnegie Mellon University, and President, CEO, and Founder of Vinomis Laboratories, a nutraceutical company that manufactures supplements based on Resveratrol, Quercetin and Red Wine Grape extracts.  He holds a BSE from Princeton, and an MBA from Stanford, and has authored numerous scientific and technical papers. 

Resveratrol + Red Wine Grape extracts + Polyphenols

Most other supplements other than Vindure 900, only include Resveratrol. While indeed Resveratrol has shown many positive health benefits, it should be remembered that the Harvard Medical School research identified seventeen (17) sirtuin-activating compounds found in red wine grapes. It is this combination of all of these polyphenols that nature produces to provide health benefits in humans.

Resveratrol + Quercetin = Bioavailability

It has been scientifically proven that the combination of Resveratrol and Quercetin (which has its own medicinal benefits) increase the bioavailability of Resveratrol in the blood stream, and maximize contact with the body’s cells.

Decades ago, scientists discovered the French Paradox, and determined that despite a high fat diet, the French lived longer and healthier, and have concluded that the reason is their daily dose of red wine.

Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006 have shown that there are natural plant extracts that can activate survival genes and mimic the longevity effects of calorie restriction, without having to dramatically restrict calorie intake.

After investigating over 20,000 compounds, 19 of these compounds were identified, and 17, all polyphenols with strong antioxidant properties, are found in red wine grapes, including Resveratrol and Quercetin. Further, these polyphenols work together, and enable one another to stay longer in the blood stream – termed bioavailability.

Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet.

Even more impressive is that 1) they lived healthier lives by the prevention and delay of age-related diseases, and 2) even obese animals, who typically have age-related complications, lived normal-aged lives.

Health Benefits

Among the benefits discovered scientific research are:

• Powerful antioxidant
• Anti-inflammatory,
• Blood thinner and anti-coagulant (reduces risk for artery clotting)
• Normalization of blood sugar (for diabetes),
• Increase mental capacity and memory,
• Increase in strength and endurance,
• Removal of amyloid-beta proteins that may cause Alzheimer’s, and
• (even an) Inhibitor of many types of cancers (lung, colon, skin, liver and pancreatic).

Can it really be that all of these age-related issues may be dealt with using simply plant polyphenols compounds? Quite possibly, the answer is yes.

Exclusive Harvard Medical School patent

Vinomis has an exclusive Harvard Medical School license for proprietary science and has formulated its products using these principals. Harvard scientists found that when certain plants are put into a stressed xenohormetic environment (dehydration, infection, heat, cold, extreme UV exposure, etc.) they produce concentrated polyphenols such as Resveratrol and Quercetin. Many grapes are grown under these stressed conditions.

Marywood University study on Vindure 900 combination

In 2006, Xenomis, LLC. conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation:

• 400 mg of 98% pure Resveratrol
• 400 mg Red Wine Grape extract
• 100 mg Quercetin

This is the identical combination of ingredients found in Vindure 900.

The Smoliga study showed significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of pure red wine grape extract.

Naturex French study

Vinomis Red Wine Grape Extract™ uses whole grape extract from Naturex, called PowerGrape. In a study in 2005, a collaboration between researchers from Avantage Nutrition and the French Agronomic Research Institute (INRA), athletes were given 400 mg of Naturex Bordeaux extract per day. Results indicated a reduction in the risk of muscular damage, improvement in sports performance, improved recovery capacity, and improved antioxidant status.

Powerful Antioxidant

Brunswick Laboratories, the leader in antioxidant testing of foods and supplements, has determined that each Vindure 900 tablet from Vinomis Laboratories has an ORAC rating of 19,638, over six times times the USDA recommended daily consumption of at least 3000 ORAC units.

Other Scientific Studies

Grape extract reduces heart disease risk. In 2006, researchers at UC Davis assessed the effect of red grape extract on metabolic syndrome, a combination of factors that increase the risk for heart disease, including high blood pressure, excess abdominal body weight, high blood cholesterol fats and high blood sugar. A study at the University of Wisconsin of 15 adults with coronary artery disease discovered that the flavenoids (types of polyphenols) in red grapes may prevent cardiovascular events.

Resveratrol may block colon cancer. The Cancer Center at UC Irvine, followed up on previous in vitro studies showing that Resveratrol blocks a cellular signaling pathway known as the WNT pathway, which has been linked to more than 85 percent of sporadic colon cancers – the most common form of colon cancer.

Beneficial Effects of Quercetin. At the University of Western Australia, in Perth, a study using 200mg of Quercetin found that dietary flavonoids may improve endothelial function and ultimately lead to beneficial cardiovascular effects.

Grape extract increases energy production in cells – In 2006, athletes in Belgium was given 400 mg of Bordeaux red grape extract per day. Results included a 14% increase in lipophile antioxidant capacity, and a 96% increase in an antioxidant involved in energy production in cells.

Decades ago, scientists also discovered the French Paradox, and determined that despite a high fat diet, the French lived longer and healthier, and have concluded that the causes had largely to do with their daily dose of Red Wine.

More recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006, coupled with many follow-on university and research laboratory studies (including University of Pennsylvania, Marywood University, Yale, University of Michigan, University of Connecticut, Wake Forest, Oregon State, University of South Carolina, and many more), have shown that there are natural plant extracts that can activate sirtuin “survival genes” which increase longevity and reduce the incidence of age-related illnesses such as diabetes, heart disease, Alzheimer’s, and even cancer.

These natural plant extracts were discovered after investigating over 20,000 compounds. Nineteen (19) of these compounds were identified, and 17 (all polyphenols with strong antioxidant properties) are found in Red Wine Grapes, including Resveratrol, Quercetin Catechin, and others. Futhermore, it has been proven that the combination of these red wine polyphenols allow them to work together, and to remain longer in the blood stream (bioavailability) after being ingested.

Extensive medical research has been conducted by university professors, pharmaceutical companies, and nutraceutical companies into the medical benefits of red wine extracts. These studies have shown many health benefits including: anti-inflammatory, blood thinning and reduced risk for artery clotting (anti-coagulant), normalization of blood sugar (for diabetes), increase mental capacity and memory, increase in strength and endurance, and even the inhibition of many types of cancers (lung, colon, skin, liver and pancreatic).

Parts of the Grape

There are basically three (3) parts that have different components of beneficial polyphenols: 1) pulp, 2) skins, and 3) seeds. Studies have been conducted with each of these components, as well as the overall combination (whole grapes), and have shown a variety of positive results. The best supplements use whole grape extracts, which ensure you’re getting the full complement of polyphenols from all parts of the red wine grapes.

Red Wine and Grape Juice

A logical question is whether or not the same health benefits can be derived from red wine and grape juice. While these liquids produce health benefits, a person would consume entirely too much alcohol and calories to get the equivalent dosage of a nutraceutical supplement.

Dosages

Assuming a high quality extraction and concentration system is used, red wine grapes can be expected to achieve up to 90% concentration of polyphenols (be sure to check the Supplement Label). If the polyphenol concentration is not listed, be cautious, as it is most likely inferior-grade product.

Approximately 500 mg of Red Wine grape extract is equivalent to one (1) bottle of high quality red wine. This is the concentration used by Dr. Smoliga in his studies, and by Naturex with their PowerGrape product.

Types of Red Wine Grape Supplements

There are two (2) broad categories of Red Wine grape supplements on the market today:

1. Pure Red Wine Grape supplements

These use a variety of different types of red wine grapes, whole grapes, grape skins, grape seeds, etc. Each claim a different amount of polyphenols and Resveratrol based upon the types of grapes used, the extraction and concentration process. Each have a slightly different blend of polyphenols, and again, the total concentration of about 90% polyphenols will be the maximum achievable level.

The maximum level of a specific polyphenol, such as Resveratrol, will generally be in the 5-10% range. So for a 500 mg red wine grape supplement, the most Resveratrol or Quercetin, for example, would be 25 – 50 mg (not very much, and well below therapeutic dosage).

2. Polyphenol Formulations with Red Wine Grape Extracts

As stated, there is only so much Resveratrol, Quercetin, Catechin, and other specific polyphenols that can be extracted and concentrated irrespective of the types of grapes, or process used. In order to maximize a particular polyphenol, it must be specifically added.

Products such as Vindure 900, for example, add an additional 400 mg of Resveratrol and 100 mg of Quercetin, which means you’re getting the Resveratrol-equivalent of over 100 bottles of red wine in a single daily dosage

Recommendations

According to Dr. Joseph Maroon in an article published by Bottom Line Health, in September 2009 (The Simple Supplement that May Prevent killer Diseases – All about resveratrol), “because Resveratrol absorption is thought to be enhanced when combined with other natural polyphenols, a mixed-polyphenol supplement is best.” [Dr. Maroon is a professor of neurological surgery at the University of Pittsburgh Medical Center (UPMC) and author of The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life ]

Red Wine Grape Studies (reference)

Grape extract and Resveratrol improves endurance and memory. In 2006, 54 sedentary adults were given a mixture of 400 mg red wine grape extract, 400 mg of Resveratrol, and 100 mg of Quercetin. Results included improved (decreased) submaximal heart rate, improved neurocognitive performance, and improved memory. By Dr. James Smoliga of Marywood University. A second study is underway with 400 mg of only pure whole red wine grape extract.

Grape extract improves athletic performance and recovery. A group of twenty athletes, aged between 18 and 34 took part in the study in 2005, a collaboration between researchers from Avantage Nutrition and the French Agronomic Research Institute (INRA). the athletes were given 400mg of Bordeaux extract per day. Results indicate that the grape extract could reduce the risk of muscular damage, improve the explosive sports performance during effort, improve recovery capacity after effort, and improve the antioxidant status in athletes.

Grape extract reduces heart disease risk. Conducted by UC Davis cardiovascular researchers in 2006, the study was the first human clinical trial to assess the effect of grape extract on people with metabolic syndrome, a combination of risk factors that increase the risk for heart disease, including high blood pressure, excess abdominal body weight, high blood cholesterol fats and high blood sugar. In 24 patients, the extract lowered blood pressure by 8-12 points.

Grape extract reduces incidence of heart attacks. A study at the University of Wisconsin of 15 adults with coronary artery disease discovered that the flavenoids in red grapes may prevent cardiovascular events. A 14 day supplementation improved endothelial function and reduced the susceptibility of LDL cholesterol to oxidation.