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READ ARTICLE in Neutraceutical World – Click Here

‘Stressed Plant’ Technology Comes to Fruition

 

Vindure 900 is billed to contain the highest dosage of Resveratrol on the market.

 

By Joanna Cosgrove 
Online Editor

 

Last November, Nutraceuticals World detailed how Pittsburgh, PA-based Xenomis LLC had licensed Harvard Medical School’s “Stressed Plant” technology with the goal of developing cutting edge resveratrol supplement applications. Flash forward to the present and there is a new supplement that boasts the highest resveratrol content of any product currently on the market. 

The product evolved out of the phenomenon known as “The French Paradox,” whereby the French live longer and healthier than Americans, despite a high saturated fat, high calorie diet, thanks apparently to the consumption of red wine. In 2003, a team of researchers at Harvard Medical School “broke the code” and discovered that 19 polyphenols activate the “SIRT” genes, and 17 of these are found in red grapes and red wine. SIRT genes produce the Sirtuin enzymes which play a key role in the aging process, and prevent many of the diseases related to aging such as diabetes, cancers, heart disease, Alzheimer’s and others.

The Harvard Medical School researchers concluded that two of the most powerful SIRT activators were Resveratrol and Quercetin. Together with an advisory board of distinguished physicians and researchers, Sewickley, PA-based Vinomis Laboratories, a spinoff company of Xenomis LLC, developed an ideal combination of these ingredients, a product called Vindure 900.

Launched in mid-June, the product is a powerful antioxidant cocktail containing 400 mg of 98% pure Resveratrol, 400 mg of red wine grape extract from Bordeaux, France, and 100 mg of high-purity Quercetin which, in addition to its own benefits, enhances the bio-availability of the Resveratrol, keeping it in the bloodstream longer. The formulation provides more than 900 mg of active ingredients in a one-per-day coated tablet.

The company said the product is “the equivalent of 100 bottles of red wine,” sans the alcohol or calories.

“[It] is the combination of Resveratrol, Quercetin and Red Wine grape polyphenols that provide the health benefits and increase the bioavailability,” explained Mark Juliano, president, Vinomis Laboratories. He added that the source of the pure resveratrol is 98% pure Polygonum cuspidatum (Japanese Knotweed), as well as that contained in the Red Wine grape extract. “This is a very expensive ingredient at over $700 per kg. Most resveratrol is either synthetic, or is only 50% pure (of course it’s the ‘other’ 50% that’s the impurities),” he said.

Independent tests conducted by Brunswick Laboratories of Norton, MA, measured the ORAC (oxygen radical absorbance capacity) of Vindure at 19,638, which is more thansix times times over the USDA recommended daily consumption of at least 3000 ORAC units—roughly equal to eight times the amount of antioxidants in a glass of pomegranate juice.

Clinical Support

One of the most exciting aspects of the product, according to Mr. Juliano, is the breadth of support it has received from human clinical trials. Most notably, in 2006 Dr. James Smoliga, professor of Exercise Physiology, College of Health and Human Services at Marywood University, studied the product’s exact combination of ingredients on human subjects. He reported that the subjects showed “dramatic increases in strength, endurance and memory/cognition.”

The Vinomis team is also eagerly awaiting the results from two current studies. Dr. Smoliga is presently testing Naturex Powergrape (which Mr. Juliano characterized as a key part of Vinomis’ grape extract), but plans a “follow on study” with Vindure 900 as it relates to endurance in human athletes. Strength, endurance, memory plus sirtuin levels, sugar levels and other biomarkers will all be examined.

Dr. Bryan Donohue, chief of cardiology at the University of Pittsburgh Medical Center, and Dr. Joseph Baur of the University of Pennsylvania School of Medicine’s Institute for Diabetes, Obesity and Metabolism, Department of Physiology, are also studying pre- and post-Vindure 900 sugar, cholesterol, Sirtuin and Resveratrol levels in human blood.

Regarding Vindure 900 patient results, Mr. Juliano said the company has been collecting patient results through a select group of doctors for several months. “We all know the long-term benefits of Resveratrol, Quercetin and Red Wine grape extracts, but we’re also getting a number of short-term results,” he said. The company’s study is ongoing, however the results so far confirm that more than 50% of patients report that after taking Vindure 2-4 weeks they’ve experienced “increased energy level (80%+), improved mental clarity, improved mood level (elimination of depression in some cases), lower appetite and weight loss.”

He added that there have also been reports of “moderation and/or lowering of blood sugar levels, lowering of cholesterol levels, [and] increased urination on patient with prostrate issues.” The only side effects noted are less sleep, though the patients attributed it to increased energy levels. “This effect is eliminated if patients take Vindure 900 in the morning,” said Mr. Juliano, and he added that the product should be taken with food.

Vindure 900 is being marketed primarily toward consumers (especially athletes and Baby Boomers) seeking to alleviate “age-related diseases” while benefitting from “increased energy” and “improved cognition.” The product is also targeting high-risk patients with elevated cholesterol, lipid and blood sugar levels via physician recommendations.

Vindure 900 is sold on Vinomis’ website, through doctors and in select pharmacies. A 30-day supply of the product (30 tablets) retails for $39.95. Mr. Juliano said there are also “deals in the works” with major nutritional supplement chains.

Vindure 900 is manufacturerd in the U.S. for Vinomis by Nutra Manufacturing of Greenville, SC, a subsidiary of General Nutrition Centers (GNC). The facility is certified by FDA, Australian TGA, USP and NSF, and complies with the latest GMPs.

Mr. Juliano and his partners—Bill Watts, formerly the CEO of GNC, David Sculley, formerly the CEO of Heinz, Dr. Brian Donohue and Dr. Joseph Maroon, Chief of Neurosurgery, UPMC—are keenly aware that consumers prefer proof over empty promises when it comes to nutritional supplements and are eager to see how the public receives their flagship Vindure 900 product. For more information about the science supporting the product, logon to Vinomis Laboratories’ website.

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• Some doctors are doing blood work for their customers
• We have called select customers at their request
• Doing surveys

We all know the long-term benefits of Resveratrol, Quercetin, and Red Wine grape extracts, but we’re also getting a number of short-term results:

Here are the results so far:

Many (>50%) customers report the following (these are all related)

• Increased energy level (80%+)
• Improved mental clarity
• Improved mood level (elimination of depression in some cases)
• Lower appetite and weight loss

Also reporting:

• Moderation and/or lower of blood sugar levels
• Lowering of cholesterol levels
• Increased urination on patient with prostrate issues (this is a good thing)

Any side effects?

• Some report less sleep due to energy levels. This effect is eliminated if patients take Vindure 900 in the morning
• Very few have reported diarrhea (this is possible with many medications or supplements)
• Recommend taking Vindure 900 with food

Here are the six (6) reasons why we truly believe this to be so.

1. Solid Research Science

Studies have been conducted at many universities including Harvard, Yale, Marywood, University of Pennsylvania, Brown, University of Queensland, University of Leicester, University of Nebraska, University of Connecticut, University of Illinois, Rutgers, etc. etc. etc. The idea of calorie restriction extending life and helping abate age-related diseases has been proven many times in organisms, fish, animals, and humans. Scientist have also proven that calorie restriction activates the Sirtuin genes, which leads to longevity and a healthier, longer life. There is significant scientific evidence that these Sirtuin or SIRT genes can be activated by giving animals Resveratrol and many other Red Wine Grape polyphenols. 

2. Personal Experience

After taking a Resveratrol supplement for 4-6 weeks, all the partners at Vinomis have reported their own personal health improvements with Vindure 900 and Resveratrol. These ranged from increased energy, to lowered cholesterol and blood sugar, to increased endurance.

3. Experiences of Our Vinomis Customers

There’s nothing like a happy customer. We have personally spoken to over 100 of our customers who are taking Vindure 900. Virtually all of them (over 90%) report short-term benefits after taking Vindure for about a month. Those benefits include 1) increased energy level, 2) moderation of blood sugar levels in diabetics, 3) improved mood, 4) weight loss, and 5) increased endurance. One person even reported that her father who has dementia was “more responsive”, which really made my day. We’re in the process of publishing a report on these customers.

4. Red Wine is Good For You

Numerous studies have shown that red wine is good for you, and most of us have heard of the French Paradox and/or seen TV programs on Oprah, 60-minutes, etc. Unfortunately, you can’t drink a case or two of wine every day. So at Vinomis, we extracted Resveratrol from Japaneses Knot Weed, and a spectrum of polyphenols from Red Wine Grapes which has the resveratrol-equivalent of over 100 bottles of wine a day, without the alcohol or calories!

5. Long Term Health Effects

Unfortunately, scientists cannot yet measure the effects of taking Resveratrol and Red Wine Grape extracts over decades or a life time. But there have been countless university and scientific studies which show benefits in the areas of heart disease, diabetes, cancer, Alzheimer’s, and many other age-related illnesses. If even a single one of these is proven to be absolutely true, it’s sure worth the money to take Vindure 900 or other high-quality Resveratrol + Red Wine Grape supplements.

6. Longevity

Everyone is skeptical of the longevity claims about Resveratrol and Red Wine Grape extracts. But you can’t argue too much with proven science that has shown that the up-regulation (increase) in SIRT genes increases lifespan from 20 – 50% in yeast, mice, fish, mammals, etc. All the other reasons are more than enough for me to take Vindure 900, and if we all live longer to boot, you can’t beat that…

Also READ:

• Resveratrol Dosage Recommendations from Scientists
• Resveratrol Dosage

You will read information on Resveratrol Dosage that tries to determine the correct Human dosage for Resveratrol from animal studies. While this is one way to approach the problem, it’s very inexact. It’s not as simple as using body weight in a (mg/pound) formula. There are many other factors including metabolism of the animal/human, etc. The best way to determine human dosage is to give it to humans — which is what we at Vinomis Laboratories did in our human clinical trials with Dr. James Smoliga (4oo mg Resveratrol, 400 mg Red Wine Extract, 100 mg Quercetin)

[MOUSE Study -- For an 80 kg (176 lb) person, the 400 mg/kg of body weight amount used in Auwerx's mouse study would come to 32,000 mg/day. Compensating for the fact that humans have slower metabolic rates than mice would change the equivalent human dose to roughly 4571 mg/day.]

The good news it that there have been several “toxicity” studies done on Resveratrol, and even at extremely high dosages (5,000 – 50,000 mg per day) there was no toxicity measured in humans.

The highest-end resveratrol supplements recommend between 400 – 1,000 mg. Note that the 1,000 mg products are actually 2 capsules, so you can always take 2 of the 400/500 mg capsules-tablets-caplets. Vindure 900 Supplement Facts

Related to this must be a discussion of bioavailability. This term refers to how “available” the Resveratrol is in the human blood stream. Numerous studies have shown that the addition of Quercetin and Red Wine Grape polyphenols significantly increase the bioavailability and keep the Resveratrol in the blood stream longer. 

Click Here to purchase Vindure 900

Read about many other Human Clinical Trials — click here

One such study was performed in 2006 by Dr. James Smoliga of Marywood University. His 90 target subjects were given a polyphenol blend of 400 mg Resveratrol dosage, 400 mg Red Wine Grape extract, and 100 mg Quercetin. [This is the identical blend as in Vindure 900 from Vinomis]

The link below is to a medical presentation given by Dr. Smoliga at the American Association of Anti Aging Conference, Orlando, FL. April 25-27, 2008: Smoliga J. M. Evaluation of Resveratrol and Other Grape Skin Polyphenols in Human Clinical Trails. 16th Annual World Congress on Anti-Aging Medicine.  

http://roth-communications.com/MP3/Orlando1539/1539-GS07c.pdf

Dr. Smoliga’s results show an increase in human endurance, performance, strength and verbal memory in the subject patients.

Dr. Smoliga is conducting ongoing research at Marywood University on Resveratrol and Red Wine Grape extracts.