As you may already know, current medical opinion is that aspirin inhibits blood clots and reduces the risk of death from heart attack and stroke. Aspirin benefits a lot of people with coronary artery disease and atherosclerosis or hardening of the arteries. It’s prescribed to those who have had a heart attack.

Aspirin works by preventing blood platelets from clumping together to form a blood clot. This process is regulated by chemicals that are known as prostaglandins. Just like you have good cholesterol and bad cholesterol or good carbs and bad carbs, you also have good prostaglandins and bad prostaglandins in the body. The good prostaglandins keep inflammation and clotting to a minimum. The bad prostaglandins trigger events that cause clotting and inflammation. Aspirin keeps the blood free-flowing, thus reducing the risk of clots.

Hungarian researchers found that high-risk cardiovascular patients can still suffer a serious vascular event (heart attack or stroke) even though they are on aspirin. The aspirin fails to stop the platelets from clumping together to form the clot in 1 out of every 5 incidents related to heart disease for this high risk group of people.

Now imagine if you are a patient with heart disease. How would you know if you are in that 20% or not? There’s no way that your friendly clinical laboratory or doctor’s office will be able to predict this. However, in research, this is measured by platelet clumping found in the blood after epinephrine or collagen is added to the blood of a person taking aspirin.

How could people predict dying from a heart attack or stroke if they were in the aspirin failure group? That thought was enough to stimulate researchers to try to solve the problem. They knew that Resveratrol had the ability to inhibit platelet clumping (aggregation) in animals. They decided to test it in humans. Those that had the highest aggregation rate were also high on the scale for aspirin failure.

And here’s the part where Resveratrol came to the rescue. Researchers found that they could influence what was happening by adding Resveratrol to the diet. Resveratrol worked best in the cases where the platelet clumping from collagen and epinephrine were at a maximal level; i.e., those who were aspirin resistant. Researchers concluded that the heart-protective effects of Resveratrol could be due to this blood clot preventative activity.

As someone with a family history of heart disease, I’m glad that Vinomis has done all the work necessary to create a great Resveratrol supplement. The Vindure 900 contains more Resveratrol than any other company on the market.

The All-Natural Supplement that May Prevent Killer Diseases

All About Resveratrol

By Mark Juliano

Thanks to stories on 60 Minutes, Oprah, Dr. Oz, and Barbara Walters, supplements based on Resveratrol now top the “hot list.”  Multiple studies conducted on laboratory animals have demonstrated the highly beneficial effects of this polyphenol (a class of plant chemicals) which is found in the skins of grapes and in red wine.

KEY ANIMAL FINDINGS

Resveratrol has been shown to enhance muscle strength, reduce fatigue, and help prevent heart disease, stroke, diabetes, and cancer.  It can help clear away the toxic proteins that cause Alzheimer’s disease, and even increase animals’ life span by 25-50%.  But can this substance do the same for humans?

AN IMPORTANT DISCOVERY

Resveratrol’s emergence as an anti-aging powerhouse began in the 1930s with the finding that calorie restriction – 30% less than a normal diet – could extend lifespan by 20-50% in both animals and humans.  In the 1990s, researchers at Harvard Medical School discovered that near starvation triggers an activation of “survival” or SIRT genes which produce enzymes that slow cellular aging.  The scientists also found that Resveratrol is the most powerful SIRT activator, especially in combination with other grape polyphenols, such as Quercetin.

CURRENT EVIDENCE

The most startling research result was found in 2003 at Harvard.  When given Resveratrol, obese mice lived as long as normal weight mice, and did not fall prey to diabetes, heart disease and other conditions.  Resveratrol appears to achieve these results through a number of mechanisms including a reduction in the inflammation which contributes to cardiovascular disease.

BREAKTHROUGH RESEARCH

A recent human study showed that drinking one and a half glasses of red wine per day reduced levels of lipid peroxide, a by-product of inflammation that damages arteries, by 40%.  At the same time, Resveratrol was shown to spark the production of the beneficial gas, nitric oxide, which increases blood vessel flexibility.  Resveratrol also thins the blood, reducing the risk for clots.

Cancer: Eighteen different types of cancer have been markedly inhibited in laboratory studies of human and animal cells.

Diabetes: Resveratrol helps normalize blood sugar levels by moving glucose out of the bloodstream and into cells, and stimulating natural insulin production.

Alzheimer’s: Resveratrol helps remove the amyloid-beta protein that causes brain damage associated with Alzheimers’s.

New Findings: In a study of 90 healthy adults, researchers at Marywood University found that a blend of 400mg of Resveratrol plus other polyphenols improved memory and sped up reaction time.

BEST SOURCES

To achieve an optimum dosage of 400mg of Resveratrol, one could consume massive quantities of grapes, red wine, or chocolate.  However, unhealthful quantities of calories, sugar, or alcohol would come along for the ride.  Look for a supplement blend with 98% pure Resveratrol extracted from the roots of polygonum cuspidatum – the Japanese Knotweed.  Ideally, Resveratrol is most effective when blended with the broad spectrum of polyphenols found in red wine grapes, and Quercetin, another powerful SIRT gene activator.

Resveratrol and Red Wine Grape Polyphenols: 

Nature’s Longevity and Healing Compounds  

Table of Contents 

Calorie Restriction and Longevity

Resveratrol Dosage

Types of Resveratrol Supplements

Recommendations for Supplements  

Resveratrol Safety

Human Clinical Trials

Consumer Testimonials 

WHITE PAPER EXCERPT: CLICK HERE to read entire White Paper

Age eventually conquers all.  As our bodies age, we undergo a significant transformation in cell structure, bone and muscle mass, hormones, immunities, and cognitive abilities.  This deterioration is compounded by cumulative stress, and the potential for heart disease, diabetes, neurological disorders such as Alzheimer’s, and cancer.  All in all, it is not a pretty picture. 

Yet, some people do age better than others, and live long healthy lives.  A growing number of people are living into their nineties and even past the century mark.  While  heredity and DNA markers surely contribute to our eventual lifespan, scientists have proven over decades of research that in addition to exercise and mental activity, diet and nutraceutical supplementation can not only prolong life, but can also allow us to lead healthier lives.  Proof that people have accepted these discoveries is evidenced by the explosive growth in health foods, organic foods, and nutritional supplements. 

Medical science has grown exponentially since the early 1900s.  During that same period, the average lifespan of humans has increased an average of 3 months each year, or a total of 30 years! Current advancements in nutrition have spawned a large nutraceutical supplement industry, and ingredients such as Resveratrol, Quercetin, and red wine grape polyphenols may be key ingredients to continued advancements in longevity research leading people to live longer, and live longer healthier.

About the Author:

Mark Juliano is an Adjunct Professor at Carnegie Mellon University, and President, CEO, and Founder of Vinomis Laboratories, a nutraceutical company that manufactures supplements based on Resveratrol, Quercetin and Red Wine Grape extracts.  He holds a BSE from Princeton, and an MBA from Stanford, and has authored numerous scientific and technical papers. 

Decades ago, scientists discovered the French Paradox, and determined that despite a high fat diet, the French lived longer and healthier, and have concluded that the reason is their daily dose of red wine.

Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006 have shown that there are natural plant extracts that can activate survival genes and mimic the longevity effects of calorie restriction, without having to dramatically restrict calorie intake.

After investigating over 20,000 compounds, 19 of these compounds were identified, and 17, all polyphenols with strong antioxidant properties, are found in red wine grapes, including Resveratrol and Quercetin. Further, these polyphenols work together, and enable one another to stay longer in the blood stream – termed bioavailability.

Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet.

Even more impressive is that 1) they lived healthier lives by the prevention and delay of age-related diseases, and 2) even obese animals, who typically have age-related complications, lived normal-aged lives.

Health Benefits

Among the benefits discovered scientific research are:

• Powerful antioxidant
• Anti-inflammatory,
• Blood thinner and anti-coagulant (reduces risk for artery clotting)
• Normalization of blood sugar (for diabetes),
• Increase mental capacity and memory,
• Increase in strength and endurance,
• Removal of amyloid-beta proteins that may cause Alzheimer’s, and
• (even an) Inhibitor of many types of cancers (lung, colon, skin, liver and pancreatic).

Can it really be that all of these age-related issues may be dealt with using simply plant polyphenols compounds? Quite possibly, the answer is yes.

Exclusive Harvard Medical School patent

Vinomis has an exclusive Harvard Medical School license for proprietary science and has formulated its products using these principals. Harvard scientists found that when certain plants are put into a stressed xenohormetic environment (dehydration, infection, heat, cold, extreme UV exposure, etc.) they produce concentrated polyphenols such as Resveratrol and Quercetin. Many grapes are grown under these stressed conditions.

Marywood University study on Vindure 900 combination

In 2006, Xenomis, LLC. conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation:

• 400 mg of 98% pure Resveratrol
• 400 mg Red Wine Grape extract
• 100 mg Quercetin

This is the identical combination of ingredients found in Vindure 900.

The Smoliga study showed significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of pure red wine grape extract.

Naturex French study

Vinomis Red Wine Grape Extract™ uses whole grape extract from Naturex, called PowerGrape. In a study in 2005, a collaboration between researchers from Avantage Nutrition and the French Agronomic Research Institute (INRA), athletes were given 400 mg of Naturex Bordeaux extract per day. Results indicated a reduction in the risk of muscular damage, improvement in sports performance, improved recovery capacity, and improved antioxidant status.

Powerful Antioxidant

Brunswick Laboratories, the leader in antioxidant testing of foods and supplements, has determined that each Vindure 900 tablet from Vinomis Laboratories has an ORAC rating of 19,638, over six times times the USDA recommended daily consumption of at least 3000 ORAC units.

Other Scientific Studies

Grape extract reduces heart disease risk. In 2006, researchers at UC Davis assessed the effect of red grape extract on metabolic syndrome, a combination of factors that increase the risk for heart disease, including high blood pressure, excess abdominal body weight, high blood cholesterol fats and high blood sugar. A study at the University of Wisconsin of 15 adults with coronary artery disease discovered that the flavenoids (types of polyphenols) in red grapes may prevent cardiovascular events.

Resveratrol may block colon cancer. The Cancer Center at UC Irvine, followed up on previous in vitro studies showing that Resveratrol blocks a cellular signaling pathway known as the WNT pathway, which has been linked to more than 85 percent of sporadic colon cancers – the most common form of colon cancer.

Beneficial Effects of Quercetin. At the University of Western Australia, in Perth, a study using 200mg of Quercetin found that dietary flavonoids may improve endothelial function and ultimately lead to beneficial cardiovascular effects.

Grape extract increases energy production in cells – In 2006, athletes in Belgium was given 400 mg of Bordeaux red grape extract per day. Results included a 14% increase in lipophile antioxidant capacity, and a 96% increase in an antioxidant involved in energy production in cells.

CLICK HERE to get to Bio-Medicine website

Red wine’s resveratrol may help battle obesity

Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study. The results will be presented at The Endocrine Society’s 90th Annual Meeting in San Francisco.

Past research found thatresveratrol protected laboratory mice that were fed a high-calorie diet from the health problems of obesity, by mimicking the effects of calorie restriction. Researchers at the University of Ulm in Germany wanted to know ifresveratrol could mimic the effects of calorie restriction in human fat cells by changing their size or function. The German team used a strain of human fat cell precursors, called preadipocytes. In the body, these cells develop into mature fat cells, according to the study’s lead author, Pamela Fischer-Posovszky, PhD, a pediatric endocrinology research fellow in the university’s Diabetes and Obesity Unit.

In the cell-based study, they found that resveratrol inhibited the pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrolhindered fat storage. Most interesting, according to Fischer-Posovszky, was that resveratrolreduced production of certain cytokines (interleukins 6 and 8), substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries. Also, resveratrol stimulated formation of a protein known to decrease the risk of heart attack. Obesity decreases this substance, called adiponectin.

The new finding is consistent with the theory that the resveratrol in red wine explains the French paradox, the observation that French people eat a relatively high-fat diet but have a low death rate from heart disease.

“Resveratrol has anti-obesity properties by exerting its effects directly on the fat cells,” Fischer-Posovszky said. “Thus, resveratrol might help to prevent development of obesity or might be suited to treatin

Excerpt:

Resveratrol – The Miracle Nutrient for Cancer, Cholesterol and Longevity

(NaturalNews) You’ve all heard the good news about resveratrol, commonly known as the “red wine nutrient.” There’s more to resveratrol than red wine, though, and it’s helpful for far more than just preventing heart disease. It’s also phenomenal for maintaining a healthy cholesterol balance and even supporting increased longevity.

As you’ll see below in quotes from health experts about resveratrol, this “miracle” nutrient is also useful for preventing many types of cancer. As you read these quotes, pay special attention to any mention of phytoalexins, as this is a class of plant-based nutrients that you’ll be hearing about much more in the future (as nutritional healing becomes more widely known).

If you want to acquire some resveratrol, there are lots of natural sources such as red wine or grape leaves (the leaves actually contain far more than the grapes themselves). The Chinese medicine herb hu zhang is also loaded with resveratrol.

CLICK HERE to read entire article

These survival genes were discovered by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School and reported in Nature Magazine in 2006. Through a variety of studies and experiments, these doctors/professors proved that calorie restriction triggered a so-called (survival) chain reaction that activates survival genes (sirtuins). This process slows cellular aging. In subsequent studies, these doctors were able to “mimic” calorie restriction and activate survival genes (without calorie restriction) with Resveratrol, and 17 other polyphenol compounds commonly found in red wine grapes.

According to Dr. Joseph Maroon, in a recent article in Bottom Line Health, “Resveratrol has been shown not only to enhance muscle strength and reduce fatigue, but also to help prevent heart disease, stroke, diabetes and cancer … clear away the toxic proteins that case Alzheimer’s disease … and even lengthen life span by 25%… Resveratrol and other polyphenols were found to increase the life span of flies by 60%, worms and flies by 30%, and mice by 25%.”

Dr. Maroon also states:

“Take a mixed-polyphenol supplement. I recommend the mixed polyphenol supplement Vindure 900, a product developed by Vinomis Laboratories based on Harvard University research…because Resveratrol absorption is thought to be enhanced when combined with other natural polyphenols, a mixed-polyphenol supplement is best.”

Tip: Yet another reason to love red wine

“Several studies have concluded that red wine may be helpful in fighting off several diseases and conditions, including high cholesterol, heart disease, various cancers and even aging.

Now, two new studies indicate that resveratrol, the antioxidant chemical in red wine, also may decrease pain and boost your love life.

An Italian study found that women who drank one or two glasses of red wine daily scored higher on the Female Sexual Function Index, a test that researchers say measures how satisfied a woman is with her sex life. The study was published in the current issue of the Journal of Sexual Medicine.

And Scottish researchers concluded that resveratrol may be beneficial in reducing the pain from inflammatory diseases such as arthritis.

While the study used only laboratory mice, researchers said resveratrol may have the same beneficial effects in humans.