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	<title>Vinomis Laboratories &#187; lifespan</title>
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		<title>Resveratrol &#8211; The Secret to Long Life</title>
		<link>http://www.vinomis.com/blog/2010/01/26/resveratrol-long-life/</link>
		<comments>http://www.vinomis.com/blog/2010/01/26/resveratrol-long-life/#comments</comments>
		<pubDate>Tue, 26 Jan 2010 18:14:36 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[News]]></category>
		<category><![CDATA[resveratrol]]></category>
		<category><![CDATA[lifespan]]></category>
		<category><![CDATA[long life]]></category>

		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=542</guid>
		<description><![CDATA[Dr. Bryan Donohue, Vinomis Chief Medical Advisor, was featured on KDKA’s Good Morning Pittsburgh show.  Dr. Donohue reviewed the thousand year history and 50 years of research on Resveratrol, all in 6 minutes.  He explained that it has always been observed that “near starvation” causes people to stop aging, as long as they don’t die [...]]]></description>
			<content:encoded><![CDATA[<p>Dr. Bryan Donohue, Vinomis Chief Medical Advisor, was featured on KDKA’s Good Morning Pittsburgh show.  Dr. Donohue reviewed the thousand year history and 50 years of research on Resveratrol, all in 6 minutes.  He explained that it has always been observed that “near starvation” causes people to stop aging, as long as they don’t die of starvation.  Scientists have discovered that this adversity activates “survival genes” in the body.  Research over the past 10 years has identified these genes as the SIRT genes, which produce Sirtuins.  Resveratrol seems to have the same affect on the SIRT genes, elevating the Sirtuins, but without the starvation.  Research on laboratory animals has confirmed that this can indeed, increase lifespan, especially in cases where obesity or other conditions might otherwise shorten it.  Resveratrol, along with Quercetin are found in red wine, dark chocolate, and other plants.</p>
<p>Dr. Donohue was asked what kind of benefits his patients on Vindure are experiencing.  In addition to almost “across the board” reports of increased energy and verve, Dr. Donahue has seen improvements in the “insulin curve” of many patients.  The science behind Resveratrol, and Vindure, says Dr. Donohue, “is jaw-dropping.”</p>
<p>See the video here: <a href="http://kdka.com/video/?id=67233@kdka.dayport.com">http://kdka.com/video/?id=67233@kdka.dayport.com</a></p>
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		<title>Extensive Resveratrol White Paper Published</title>
		<link>http://www.vinomis.com/blog/2009/10/14/new-resveratrol-extensive-white-paper-published/</link>
		<comments>http://www.vinomis.com/blog/2009/10/14/new-resveratrol-extensive-white-paper-published/#comments</comments>
		<pubDate>Wed, 14 Oct 2009 19:42:38 +0000</pubDate>
		<dc:creator>markjuliano</dc:creator>
				<category><![CDATA[Articles]]></category>
		<category><![CDATA[Science]]></category>
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		<category><![CDATA[calorie restriction]]></category>
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		<category><![CDATA[Longevity]]></category>
		<category><![CDATA[mark juliano]]></category>
		<category><![CDATA[nutraceutical]]></category>
		<category><![CDATA[nutrition]]></category>
		<category><![CDATA[polyphenols]]></category>
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		<category><![CDATA[red wine extract]]></category>
		<category><![CDATA[red wine grapes]]></category>
		<category><![CDATA[resveratrol and red wine grape polyphenols]]></category>
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		<category><![CDATA[resveratrol safety]]></category>
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		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=479</guid>
		<description><![CDATA[An extensive White Paper on Resveratrol, Red Wine Grapes, and Polyphenols has been published by Mark Juliano, President of Vinomis Laboratories. The 15-page white paper covers a broad range of related topics. CLICK HERE to read entire White Paper.
Resveratrol and Red Wine Grape Polyphenols: 
Nature’s Longevity and Healing Compounds  
 
Table of Contents 
Calorie Restriction and Longevity
Resveratrol Dosage
Types [...]]]></description>
			<content:encoded><![CDATA[<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">An extensive White Paper on Resveratrol, Red Wine Grapes, and Polyphenols has been published by Mark Juliano, President of Vinomis Laboratories. The 15-page white paper covers a broad range of related topics. <a href="http://www.vinomis.com/images/WhitePaperResveratrol.pdf"><strong>CLICK HERE to read entire White Paper</strong></a><strong>.</strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 20.0px Cambria; min-height: 23.0px;"><strong><span style="color: #800000;">Resveratrol and Red Wine Grape Polyphenols: </span></strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 20.0px Cambria;"><strong><em><span style="color: #800000;">Nature’s Longevity and Healing Compounds</span> </em></strong><span style="font: 12.0px Cambria;"> </span></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 20.0px Cambria; min-height: 23.0px;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;"><strong>Table of Contents </strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;">Calorie Restriction and Longevity</p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;">Resveratrol Dosage</p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;">Types of Resveratrol Supplements</p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;">Recommendations for Supplements  </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;"><strong><span style="font-weight: normal;">Resveratrol Safety</span></strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;"><strong><span style="font-weight: normal;">Human Clinical Trials </span></strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Cambria;"><strong><span style="font-weight: normal;">Consumer Testimonials </span></strong></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">WHITE PAPER EXCERPT: <a href="http://www.vinomis.com/images/WhitePaperResveratrol.pdf"><strong>CLICK HERE to read entire White Paper</strong></a></p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">Age eventually conquers all.  As our bodies age, we undergo a significant transformation in cell structure, bone and muscle mass, hormones, immunities, and cognitive abilities.  This deterioration is compounded by cumulative stress, and the potential for heart disease, diabetes, neurological disorders such as Alzheimer’s, and cancer.  All in all, it is not a pretty picture. </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times; min-height: 14.0px;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">Yet, some people do age better than others, and live long healthy lives.  A growing number of people are living into their nineties and even past the century mark.  While  heredity and DNA markers surely contribute to our eventual lifespan, scientists have proven over decades of research that in addition to exercise and mental activity, diet and nutraceutical supplementation can not only prolong life, but can also allow us to lead healthier lives.  Proof that people have accepted these discoveries is evidenced by the explosive growth in health foods, organic foods, and nutritional supplements. </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">Medical science has grown exponentially since the early 1900s.  During that same period, the average lifespan of humans has increased an average of 3 months each year, or a total of 30 years! Current advancements in nutrition have spawned a large nutraceutical supplement industry, and ingredients such as Resveratrol, Quercetin, and red wine grape polyphenols may be key ingredients to continued advancements in longevity research leading people to live longer, and live longer healthier.</p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;"> </p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;">About the Author:</p>
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Times;"><strong>Mark Juliano</strong> is an Adjunct Professor at Carnegie Mellon University, and President, CEO, and Founder of Vinomis Laboratories, a nutraceutical company that manufactures supplements based on Resveratrol, Quercetin and Red Wine Grape extracts.  He holds a BSE from Princeton, and an MBA from Stanford, and has authored numerous scientific and technical papers. </p>
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		<title>Scientists Find Path to Fountain of Youth</title>
		<link>http://www.vinomis.com/blog/2009/10/03/scientists-find-path-to-fountain-of-youth/</link>
		<comments>http://www.vinomis.com/blog/2009/10/03/scientists-find-path-to-fountain-of-youth/#comments</comments>
		<pubDate>Sat, 03 Oct 2009 13:05:57 +0000</pubDate>
		<dc:creator>markjuliano</dc:creator>
				<category><![CDATA[Articles]]></category>
		<category><![CDATA[News]]></category>
		<category><![CDATA[age related diseases]]></category>
		<category><![CDATA[fountain of youth]]></category>
		<category><![CDATA[harvard medical school]]></category>
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		<category><![CDATA[university college london]]></category>
		<category><![CDATA[vindure]]></category>
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		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=455</guid>
		<description><![CDATA[Scientists find path to &#8216;fountain of youth&#8217;
by Jean-Louis Santini –
The following article was just published. These are the same effects produced by red wine grape polyphenols and resveratrol as sighted in the article.
EXCERPT &#8211; CLICK to read entire article
WASHINGTON (AFP) – The fountain of youth may exist after all, as a study showed that scientists have [...]]]></description>
			<content:encoded><![CDATA[<h2>Scientists find path to &#8216;fountain of youth&#8217;</h2>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;"><cite style="font-style: normal; font-weight: normal; font-family: arial, verdana, sans-serif; color: #777777; font-size: 100%;">by Jean-Louis Santini </cite>–</p>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;">The following article was just published. These are the same effects produced by red wine grape polyphenols and resveratrol as sighted in the article.</p>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;"><a href="http://news.yahoo.com/s/afp/20091002/sc_afp/healthscienceusbritainbiology">EXCERPT &#8211; CLICK to read entire article</a></p>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;">WASHINGTON (AFP) – The fountain of youth may exist after all, as a study showed that scientists have discovered means to extend the lifespan of mice and primates.</p>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;">The key to eternal &#8212; or at least prolonged &#8212; youth lies in <span id="lw_1254496290_0">genetic manipulation</span> that mimics the health benefits of reducing <span id="lw_1254496290_1" style="border-bottom-style: dashed; border-bottom-width: 1px; border-bottom-color: #0066cc; cursor: pointer;">calorie intake</span>, suggesting that aging and age-related diseases can be treated.</p>
<p style="padding-top: 0px; padding-right: 0px; padding-left: 0px; padding-bottom: 1em; line-height: 145%; margin: 0px;">Scientists from the Institute of Healthy Ageing at <span id="lw_1254496290_2" style="cursor: pointer; background-image: initial; background-repeat: initial; background-attachment: initial; -webkit-background-clip: initial; -webkit-background-origin: initial; background-color: transparent; border-bottom-style: none; border-bottom-width: initial; border-bottom-color: initial; background-position: initial initial;">University College London</span> (UCL) extended the lifespan of mice by up to a fifth and reduced the number of age-related diseases affecting the animals </p>
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		<title>Published Article &#8211; A key to Human Longevity</title>
		<link>http://www.vinomis.com/blog/2009/09/30/published-article-a-key-to-human-longevity/</link>
		<comments>http://www.vinomis.com/blog/2009/09/30/published-article-a-key-to-human-longevity/#comments</comments>
		<pubDate>Thu, 01 Oct 2009 02:08:41 +0000</pubDate>
		<dc:creator>markjuliano</dc:creator>
				<category><![CDATA[Articles]]></category>
		<category><![CDATA[antioxidant]]></category>
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		<category><![CDATA[human lifespan]]></category>
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		<category><![CDATA[Longevity]]></category>
		<category><![CDATA[mark juliano]]></category>
		<category><![CDATA[nutraceutical]]></category>
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		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=449</guid>
		<description><![CDATA[Article has been published by Mark Juliano, President of Vinomis Laboratories in GoArticles online.
Click &#8220;A Key to Human Longevity&#8221; to read entire article
Excerpt:
&#8220;When asked, &#8220;would you want to live to 150, 200 or 500 years old?&#8221; most people answer, &#8220;NO!&#8221; Upon additional probing, generally one of two explanations arises.
One, we weren&#8217;t meant to live twice [...]]]></description>
			<content:encoded><![CDATA[<p>Article has been published by Mark Juliano, President of Vinomis Laboratories in GoArticles online.</p>
<p><a href="http://www.goarticles.com/cgi-bin/showa.cgi?C=1899855">Click &#8220;A Key to Human Longevity&#8221; to read entire article</a></p>
<p>Excerpt:</p>
<p>&#8220;When asked, &#8220;would you want to live to 150, 200 or 500 years old?&#8221; most people answer, &#8220;NO!&#8221; Upon additional probing, generally one of two explanations arises.</p>
<p style="margin-top: 0px; margin-right: 5px; margin-bottom: 5px; margin-left: 5px; padding: 0px;">One, we weren&#8217;t meant to live twice as long (or forever). Frankly, I don&#8217;t really believe this answer. In Classical Greece and Rome, the average life expectancy was about 25 years old. In the early 1900s, it was 35 &#8211; 40 worldwide. Since the year 1900, human lifespan has increased about 3 months each year. So over the 100-year century, average lifespan increased 300 months, or 25 years.</p>
<p style="margin-top: 0px; margin-right: 5px; margin-bottom: 5px; margin-left: 5px; padding: 0px;">Not surprisingly, I don&#8217;t find many people volunteering to take 25 years off of their own lives. In fact, just the opposite is true. People will do almost anything to live longer. Pharmaceutical companies, doctors, patients and their families have demonstrated that if a cancer drug can increase the lifespan of a terminally ill person by only 6 &#8211; 12 months, the drug will sell over $1 Billion per year.</p>
<p style="margin-top: 0px; margin-right: 5px; margin-bottom: 5px; margin-left: 5px; padding: 0px;">Given the acceleration of medical and nutritional advancements, it is certainly reasonable to assume that humans will have an average lifespan well over 100 years within this century, and lifespan could double in the subsequent century.</p>
<p style="margin-top: 0px; margin-right: 5px; margin-bottom: 5px; margin-left: 5px; padding: 0px;">The second explanation I hear is more illuminating. People say, &#8220;I wouldn&#8217;t want to prolong my life if it meant living like many old people I know.&#8221; In other words, they&#8217;d only choose to live that much longer if they could live a healthy life.&#8221;</p>
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		<title>New York Times article on Resveratrol</title>
		<link>http://www.vinomis.com/blog/2009/09/30/new-york-times-article-on-resveratrol/</link>
		<comments>http://www.vinomis.com/blog/2009/09/30/new-york-times-article-on-resveratrol/#comments</comments>
		<pubDate>Wed, 30 Sep 2009 16:46:32 +0000</pubDate>
		<dc:creator>markjuliano</dc:creator>
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		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=447</guid>
		<description><![CDATA[
Near Term Prospects for Increased Longevity

NY Times: “In five or six or seven years,” said Christoph Westphal, Sirtris co-founder [Sirtis was bought by GlaxoSmithKline for $720 million], “there will be drugs that prolong longevity.” [H/T Michael Annisimov, Accelerating Future]
Why wait?
There&#8217;s 98% pure and natural Resveratrol available today. Pharmaceutical companies want you to wait until their drugs are [...]]]></description>
			<content:encoded><![CDATA[<p><a name="7428667948602397736"></a></p>
<h3 style="margin-top: 0.25em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 4px; padding-left: 0px; font-size: 140%; font-weight: normal; line-height: 1.4em; color: #cc6600;"><a style="display: block; text-decoration: none; color: #cc6600; font-weight: normal;" href="http://nextbigfuture.com/2009/09/near-term-prospects-for-increased.html">Near Term Prospects for Increased Longevity</a></h3>
<div>
<p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.75em; margin-left: 0px; line-height: 1.6em;"><a style="color: #5588aa; text-decoration: none;" href="http://www.nytimes.com/2009/09/29/science/29aging.html?_r=1&amp;hp" target="blank">NY Times: “In five or six or seven years,” said Christoph Westphal, Sirtris co-founder [Sirtis was bought by GlaxoSmithKline for $720 million], “there will be drugs that prolong longevity.”</a> [H/T <a style="color: #5588aa; text-decoration: none;" href="http://www.acceleratingfuture.com/michael/blog/2009/09/nyt-quest-for-a-long-life-gains-scientific-respect/" target="blank">Michael Annisimov, Accelerating Future</a>]</p>
<h2>Why wait?</h2>
<p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.75em; margin-left: 0px; line-height: 1.6em;">There&#8217;s 98% pure and natural Resveratrol available today. Pharmaceutical companies want you to wait until their drugs are ready, but you can purchase products like <a href="http://www.vinomis.com">Vindure 900 from Vinomis Laboratories</a> today. The ingredient dosages in these products have been proven in laboratory tests of humans and animals to have similar effects to those mentioned about the Sirtris product &#8212; blood sugar levels in diabetics, increased lifespan, cancer prevention, etc. all with no side effects.</p>
<p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.75em; margin-left: 0px; line-height: 1.6em;">Below is the rest of the article, and a <a href="http://nextbigfuture.com/2009/09/near-term-prospects-for-increased.html">LINK to it:</a></p>
<p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.75em; margin-left: 0px; line-height: 1.6em;"><em>SRT-501, the company’s special formulation of resveratrol, is being tested against two cancers, multiple myeloma and colon cancer that has spread to the liver. A chemical mimic of resveratrol, known as SRT-2104, is in a Phase 2 trial for Type 2 diabetes, and in a Phase 1 trial in elderly patients. (Phase 1 trials test for safety, Phase 2 for efficacy.)</p>
<p>Dr. Gallagher said that unpublished tests in mice showed that another chemical mimic, SRT-1720, increased both </em><a id="KonaLink2" style="position: static; color: blue !important; text-decoration: underline; cursor: pointer; font-family: verdana; background-image: none !important; background-repeat: initial !important; background-attachment: initial !important; -webkit-background-clip: initial !important; -webkit-background-origin: initial !important; background-color: transparent !important; text-transform: none !important; display: inline !important; font-variant: normal; top: 0px; right: 0px; bottom: 0px; left: 0px; background-position: initial initial !important; padding: 0px !important; margin: 0px; border: 0px !important none !important transparent !important;" href="http://nextbigfuture.com/2009/09/near-term-prospects-for-increased.html#" target="undefined"><span style="color: blue !important; font-weight: normal; font-size: 13px; position: static;"><span style="font-family: Georgia; font-weight: normal; font-size: 13px; position: static; border-top-width: 0px !important; border-top-style: none !important; border-top-color: initial !important; border-left-width: 0px !important; border-left-style: none !important; border-left-color: initial !important; border-right-width: 0px !important; border-right-style: none !important; border-right-color: initial !important; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: initial; padding-top: 0px !important; padding-right: 0px !important; padding-bottom: 1px !important; padding-left: 0px !important; color: blue; background-image: none; background-repeat: initial; background-attachment: initial; -webkit-background-clip: initial; -webkit-background-origin: initial; background-color: transparent; width: auto !important; float: none !important; display: inline !important; background-position: initial initial;"><em>health</em></span></span></a><em> and lifespan; after two years, twice as many mice taking the drug were alive compared with the undosed animals. </em><a id="KonaLink0" style="position: static; color: blue !important; text-decoration: underline; cursor: pointer; font-family: verdana; background-image: none !important; background-repeat: initial !important; background-attachment: initial !important; -webkit-background-clip: initial !important; -webkit-background-origin: initial !important; background-color: transparent !important; text-transform: none !important; display: inline !important; font-variant: normal; top: 0px; right: 0px; bottom: 0px; left: 0px; background-position: initial initial !important; padding: 0px !important; margin: 0px; border: 0px !important none !important transparent !important;" href="http://nextbigfuture.com/2009/09/near-term-prospects-for-increased.html#" target="undefined"><span style="color: blue !important; font-weight: normal; font-size: 13px; position: static;"><span style="font-family: Georgia; font-weight: normal; font-size: 13px; position: static; border-top-width: 0px !important; border-top-style: none !important; border-top-color: initial !important; border-left-width: 0px !important; border-left-style: none !important; border-left-color: initial !important; border-right-width: 0px !important; border-right-style: none !important; border-right-color: initial !important; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: initial; padding-top: 0px !important; padding-right: 0px !important; padding-bottom: 1px !important; padding-left: 0px !important; color: blue; background-image: none; background-repeat: initial; background-attachment: initial; -webkit-background-clip: initial; -webkit-background-origin: initial; background-color: transparent; width: auto !important; float: none !important; display: inline !important; background-position: initial initial;"><em>Resveratrol</em></span></span></a><em> itself has not been shown to increase lifespan in normal mice, although it does so in obese mice, laboratory roundworms and flies.</p>
<p>Sirtris has so far been doubly fortunate. No severe side effects have yet emerged from the </em><a id="KonaLink3" style="position: static; color: blue !important; text-decoration: underline; cursor: pointer; font-family: verdana; background-image: none !important; background-repeat: initial !important; background-attachment: initial !important; -webkit-background-clip: initial !important; -webkit-background-origin: initial !important; background-color: transparent !important; text-transform: none !important; display: inline !important; font-variant: normal; top: 0px; right: 0px; bottom: 0px; left: 0px; background-position: initial initial !important; padding: 0px !important; margin: 0px; border: 0px !important none !important transparent !important;" href="http://nextbigfuture.com/2009/09/near-term-prospects-for-increased.html#" target="undefined"><span style="color: blue !important; font-weight: normal; font-size: 13px; position: static;"><span style="font-family: Georgia; font-weight: normal; font-size: 13px; position: static; border-top-width: 0px !important; border-top-style: none !important; border-top-color: initial !important; border-left-width: 0px !important; border-left-style: none !important; border-left-color: initial !important; border-right-width: 0px !important; border-right-style: none !important; border-right-color: initial !important; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: initial; padding-top: 0px !important; padding-right: 0px !important; padding-bottom: 1px !important; padding-left: 0px !important; color: blue; background-image: none; background-repeat: initial; background-attachment: initial; -webkit-background-clip: initial; -webkit-background-origin: initial; background-color: transparent; width: auto !important; float: none !important; display: inline !important; background-position: initial initial;"><em>clinical </em></span><span style="font-family: Georgia; font-weight: normal; font-size: 13px; position: static; border-top-width: 0px !important; border-top-style: none !important; border-top-color: initial !important; border-left-width: 0px !important; border-left-style: none !important; border-left-color: initial !important; border-right-width: 0px !important; border-right-style: none !important; border-right-color: initial !important; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: initial; padding-top: 0px !important; padding-right: 0px !important; padding-bottom: 1px !important; padding-left: 0px !important; color: blue; background-image: none; background-repeat: initial; background-attachment: initial; -webkit-background-clip: initial; -webkit-background-origin: initial; background-color: transparent; width: auto !important; float: none !important; display: inline !important; background-position: initial initial;"><em>trials</em></span></span></a><em>. The company has also been lucky in having apparently picked the right horse, or at least a good one, in a fast-developing field. </p>
<p>Sirtuins may not be the most important genes for longevity, Dr. Sinclair conceded at the conference, because the pathways controlled by the sirtuins, TOR and the others “all talk to each other, often by feedback loops.” </p>
<p>Many theories of aging attribute senescence to the inexorable buildup of mutations in a person’s DNA. Dr. Sinclair said that in his view “aging can be reversed” because the DNA mutations did not directly cause aging.</em></p>
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		<title>Calorie Restriction, Resveratrol and Longevity</title>
		<link>http://www.vinomis.com/blog/2009/09/09/calorie-restriction-resveratrol-and-longevity/</link>
		<comments>http://www.vinomis.com/blog/2009/09/09/calorie-restriction-resveratrol-and-longevity/#comments</comments>
		<pubDate>Wed, 09 Sep 2009 21:10:01 +0000</pubDate>
		<dc:creator>markjuliano</dc:creator>
				<category><![CDATA[Articles]]></category>
		<category><![CDATA[Science]]></category>
		<category><![CDATA[resveratrol]]></category>
		<category><![CDATA[alzheimer's]]></category>
		<category><![CDATA[anti-coagulant]]></category>
		<category><![CDATA[anti-inflammatory]]></category>
		<category><![CDATA[antioxidant]]></category>
		<category><![CDATA[bioavailability]]></category>
		<category><![CDATA[calorie restriction]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[colon cancer]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[dr. david sinclair]]></category>
		<category><![CDATA[dr. joseph baur]]></category>
		<category><![CDATA[french paradox]]></category>
		<category><![CDATA[harvard medical school]]></category>
		<category><![CDATA[lifespan]]></category>
		<category><![CDATA[liver cancer]]></category>
		<category><![CDATA[Longevity]]></category>
		<category><![CDATA[nutraceutical]]></category>
		<category><![CDATA[pharmaceutical]]></category>
		<category><![CDATA[polyphenols]]></category>
		<category><![CDATA[quercetin]]></category>
		<category><![CDATA[red wine grape extracts]]></category>
		<category><![CDATA[sirtuin]]></category>
		<category><![CDATA[skin cancer]]></category>
		<category><![CDATA[survival genes]]></category>

		<guid isPermaLink="false">http://www.vinomis.com/blog/?p=415</guid>
		<description><![CDATA[Researchers have known since the 1930s that organisms, animals, and even humans can live longer, healthier lives through calorie restriction, which activates “survival genes” later discovered to be sirtuin (SIRT) genes and enzymes. Unfortunately, in order to achieve these significant increases in lifespan, humans would need to eat a near-starvation diet, which is not only [...]]]></description>
			<content:encoded><![CDATA[<p>Researchers have known since the 1930s that organisms, animals, and even humans can live longer, healthier lives through <a href="http://www.vinomis.com/vindure/CalorieRestriction.do">calorie restriction</a>, which activates “survival genes” later discovered to be <em>sirtuin</em> (SIRT) genes and enzymes. Unfortunately, in order to achieve these significant increases in lifespan, humans would need to eat a near-starvation diet, which is not only virtually impossible, but unpleasant and frankly dangerous. Decades ago, scientists also discovered the <a href="http://www.vinomis.com/vindure/FrenchParadox.do">French Paradox</a>, and determined that despite a high fat diet, the French lived longer and healthier, and have concluded that the causes had largely to do with their daily dose of red wine.</p>
<p>Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006, coupled with many follow-on university and research laboratory studies (including University of Pennsylvania, Marywood University, Yale, University of Michigan, University of Connecticut, Wake Forest, Oregon State, University of South Carolina, Ohio State, and many more), have shown that there are natural plant extracts that can activate sirtuins and mimic the longevity effects of calorie restriction, <span style="text-decoration: underline;">without</span> having to dramatically restrict calorie intake.</p>
<p>These natural plant extracts were discovered after investigating over 20,000 compounds. Nineteen (19) of these compounds were identified, and 17 (all polyphenols with strong <a href="http://www.vinomis.com/vindure/PowerfulAntioxidant.do">antioxidant</a> properties) are found in red wine grapes, including <a href="http://www.vinomis.com/vindure/Resveratrol.do">Resveratrol</a> and <a href="http://www.vinomis.com/vindure/Quercetin.do">Quercetin</a>. Futhermore, it has been proven that the combination of these polyphenols allow them to work together, and to remain in the blood stream (bioavailability), and stay in contact with cells longer after being ingested.</p>
<p>Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet. Even more impressive is that these studies have shown that 1) animals also lived healthier lives due to the prevention and/or delay of the onset of age-related diseases such as diabetes, neurological disorders, heart disease, and cancer, and 2) even obese animals, who would normally have many complications, lived normal-aged lives.</p>
<p><a href="http://www.vinomis.com/vindure/Resveratrol.do">Resveratrol</a> and red grape polyphenols are “all the rage” these days, and supply and demand is growing in leaps and bounds in terms of its inclusion in supplements, foods, drinks, etc. However, it should again be noted that while Resveratrol has the highest SIRT gene activation, other polyphenols found in red wine grapes such as Quercetin and Catechins, are not far behind, and work in concert with Resveratrol.</p>
<p><strong><span style="text-decoration: underline;">Latest Medical Research</span></strong></p>
<p>Extensive medical research has been conducted by university professors, pharmaceutical companies, and nutraceutical companies into the medical benefits of red wine extracts, Quercetin, and Resveratrol ingredients.</p>
<p>These studies have shown many health benefits including: anti-inflammatory, blood thinning and reduced risk for artery clotting (anti-coagulant), normalization of blood sugar (for diabetes), increase mental capacity and memory, increase in strength and endurance, removal of amyloid-beta proteins that may cause brain damage associated with Alzheimer’s, and even the inhibition of many types of cancers (lung, colon, skin, liver and pancreatic).</p>
<p>Can it really be that all of these age-related issues may be dealt with using simply plant polyphenols compounds? Quite possibly, the answer is yes.</p>
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