New Miller School Mitochondria Research Could Impact Effects of Aging

from HealthCanal.com

A research group led by Carlos T. Moraes, Ph.D., professor of neurology and cell biology and anatomy at the Miller School, has published new findings about how increased mitochondrial levels may improve overall health and increase longevity.

According to the article published in the Proceedings of the National Academy of Science, the researchers increased the amount of mitochondria in a mouse model by a transgenic expression of a gene called PGC-1α. The protein produced by this gene controls the expression of many genes that are involved in mitochondrial biogenesis.

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Resveratrol and Red Wine Grape Polyphenols: 

Nature’s Longevity and Healing Compounds  

Table of Contents 

Calorie Restriction and Longevity

Resveratrol Dosage

Types of Resveratrol Supplements

Recommendations for Supplements  

Resveratrol Safety

Human Clinical Trials

Consumer Testimonials 

WHITE PAPER EXCERPT: CLICK HERE to read entire White Paper

Age eventually conquers all.  As our bodies age, we undergo a significant transformation in cell structure, bone and muscle mass, hormones, immunities, and cognitive abilities.  This deterioration is compounded by cumulative stress, and the potential for heart disease, diabetes, neurological disorders such as Alzheimer’s, and cancer.  All in all, it is not a pretty picture. 

Yet, some people do age better than others, and live long healthy lives.  A growing number of people are living into their nineties and even past the century mark.  While  heredity and DNA markers surely contribute to our eventual lifespan, scientists have proven over decades of research that in addition to exercise and mental activity, diet and nutraceutical supplementation can not only prolong life, but can also allow us to lead healthier lives.  Proof that people have accepted these discoveries is evidenced by the explosive growth in health foods, organic foods, and nutritional supplements. 

Medical science has grown exponentially since the early 1900s.  During that same period, the average lifespan of humans has increased an average of 3 months each year, or a total of 30 years! Current advancements in nutrition have spawned a large nutraceutical supplement industry, and ingredients such as Resveratrol, Quercetin, and red wine grape polyphenols may be key ingredients to continued advancements in longevity research leading people to live longer, and live longer healthier.

About the Author:

Mark Juliano is an Adjunct Professor at Carnegie Mellon University, and President, CEO, and Founder of Vinomis Laboratories, a nutraceutical company that manufactures supplements based on Resveratrol, Quercetin and Red Wine Grape extracts.  He holds a BSE from Princeton, and an MBA from Stanford, and has authored numerous scientific and technical papers. 

Click “A Key to Human Longevity” to read entire article

Excerpt:

“When asked, “would you want to live to 150, 200 or 500 years old?” most people answer, “NO!” Upon additional probing, generally one of two explanations arises.

One, we weren’t meant to live twice as long (or forever). Frankly, I don’t really believe this answer. In Classical Greece and Rome, the average life expectancy was about 25 years old. In the early 1900s, it was 35 – 40 worldwide. Since the year 1900, human lifespan has increased about 3 months each year. So over the 100-year century, average lifespan increased 300 months, or 25 years.

Not surprisingly, I don’t find many people volunteering to take 25 years off of their own lives. In fact, just the opposite is true. People will do almost anything to live longer. Pharmaceutical companies, doctors, patients and their families have demonstrated that if a cancer drug can increase the lifespan of a terminally ill person by only 6 – 12 months, the drug will sell over $1 Billion per year.

Given the acceleration of medical and nutritional advancements, it is certainly reasonable to assume that humans will have an average lifespan well over 100 years within this century, and lifespan could double in the subsequent century.

The second explanation I hear is more illuminating. People say, “I wouldn’t want to prolong my life if it meant living like many old people I know.” In other words, they’d only choose to live that much longer if they could live a healthy life.”

Resveratrol and Red Wine Grape Polyphenols – Nature’s Healing Compounds

Except from the Article:

“Researchers have known since the 1930s that organisms, animals, and even humans can live a longer, healthier lives through calorie restriction, which activates “survival genes” later discovered to be sirtuin (SIRT) genes and enzymes. Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006, coupled with many follow on studies, have shown that there are natural plant extracts that can activate sirtuins and mimic calorie restriction, without having to dramatically restrict calorie intake.

These natural plant extracts were discovered after investigating over 20,000 compounds. Nineteen (19) of these compounds (all polyphenols with strong antioxidant properties) were identified, and 17 are found in red wine grapes, including Resveratrol and Quercetin.

Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet.”

“Medical science has grown exponentially over the last century. During that period, the average lifespan of humans has increased an average of 3 months each year, or 30 years total. Current advancements in nutrition, such as the discovery of Resveratrol, Quercetin, and red wine grape polyphenols may be a key ingredient to continued advancements in longevity research leading to longer, healthier lives.”

Customers report increased energy, endurance, mood, lower blood pressure, lower sugar levels, and weight loss.

Pittsburgh, PA – September 21, 2009 – Vinomis customers have been taking its Vindure 900 product since May 2009. Vindure 900 contains a highly-concentrated blend of 400 mg of 98% pure Resveratrol, 400 mg of Vinomis™ Red Wine Grape extract (90% polyphenols), and 100 mg of Quercetin.

Customers have been commenting on Vinomis’ blogs, forums, via telephone, and in-person from real-world people who have taken Vindure 900. While these testimonials are not scientific in the sense of including medically approved studies, advanced statistical analysis, in-depth blood analysis, etc., they are nonetheless important and relevant to the overall scientific body-of-knowledge about Resveratrol, Quercetin and red wine grape extracts. Below are some of the testimonials reported by people taking Vindure 900.

These anecdotal testimonials are all in the words of the consumers themselves. What is most important is the similarity and consistency of results reported after taking the Vindure 900 supplements for 2-to-6 weeks. In addition, these results are consistent with the human trials, and biological laboratory analysis in human cells and animal studies. Multiple consumers have reported the following:

-       Increased endurance

-       Increased energy level

-       Elevated mood

-       Weight loss

-       Lower blood pressure

-       Lower blood sugar levels

“My recovery rate is surprising everyone.” – Lynn G., Mammoth Lakes, CA

“Four weeks ago, I had a lung removed at Stanford Medical Center. Coming back up to 8000 feet from sea level always makes breathing more difficult, but with one lung, it’s a lot worse. Since starting on Vindure a few weeks ago, my strength has increased remarkably, and my recovery rate is surprising everyone. I’m now out walking again, and hope to resume hiking in the Sierras soon.”

“My wife said to me – what’s with you?” – Harvey K., Atlanta, GA

“After 30 days on Vindure, I am full of energy, and waking up an hour earlier.  That extra hour a day of activity has translated to an 8 lb. weight loss.   This stuff really works! I’m having my blood work done next month and looking forward to the results.”

“My blood pressure and blood sugar are finally under control.” – Amon T., Washington, PA

“My doctor recommended Vindure 900. After one month, my blood pressure and sugar are finally under control.”

“Vindure has nearly doubled my endurance.” – Brian D., Waynesburg, PA

“I am a 45 year old Triathlete, and alternate my training between biking, swimming, and running. In April, I participated in a 48 mile bike race. By the end of the race, I was suffering from severe cramping and muscle lock up. In May, I began taking Vindure, and after only three weeks, the results I experienced were remarkable. While biking, my heart rate is lower, the cramps have nearly disappeared, and my recovery time is faster. In June, I participated in the MS150 event, and cycled 88 miles, the farthest I have ever achieved. I experienced virtually no cramping despite going twice as far, and my recovery time was dramatically reduced. I heartily recommend Vindure to every athlete!”

“I’ve lost 12 lbs in 3-1/2 Weeks.” – Ed Z. – Clarksville, PA

“I started taking Vindure about 3-1/2 weeks ago, and I’m down 12 lbs. I have found that as long as I don’t eat out of habit, and only eat when I’m hungry, I will continue to shed pounds, and Vindure has definitely reduced my appetite. My energy level is up, too!”

“So far I’ve lost 7 lbs in just 4 weeks, I’m happy with that.” – Marci S. – Washington, PA

I started Weight Watchers (WW) a month ago. I’ve been taking Vindure 900 for two months. I’m following WW by the letter which I’ve not been able to do in the past due to hunger issues. My appetite has always been an issue w/my weight increases and decreases. I’ve been able to control my eating because the Vindure 900 is decreasing that “have to eat” feeling I get.

“I as well have been taking Vinomis for about three weeks now – I cannot imagine never not taking it again.” – Tao – New York.

I have more energy, I feel that I have lost a little weight and excited about loosing more. However the best benefit is that I suffer form low-blood sugar and when I don’t have time to eat – my blood sugar plummets. These episodes would happen a few times a week as well as I would have to be aware of eating and drinking the right things to avoid the issues. For three weeks, since I have been taking the Vinomis – not one low blood sugar episode!

Vindure is available through the company’s website at www.vinomis.com, and through a network of medical professionals who are recommending Vindure to patients.  

Contact:
Barry Yarkoni
Vice President, Marketing
Vinomis Laboratories, LLC
323-282-7224 direct
BarryY@Vinomis.com

Most recently, discoveries by Dr. Joseph Baur and Dr. David Sinclair at Harvard Medical School in 2006, coupled with many follow-on university and research laboratory studies (including University of Pennsylvania, Marywood University, Yale, University of Michigan, University of Connecticut, Wake Forest, Oregon State, University of South Carolina, Ohio State, and many more), have shown that there are natural plant extracts that can activate sirtuins and mimic the longevity effects of calorie restriction, without having to dramatically restrict calorie intake.

These natural plant extracts were discovered after investigating over 20,000 compounds. Nineteen (19) of these compounds were identified, and 17 (all polyphenols with strong antioxidant properties) are found in red wine grapes, including Resveratrol and Quercetin. Futhermore, it has been proven that the combination of these polyphenols allow them to work together, and to remain in the blood stream (bioavailability), and stay in contact with cells longer after being ingested.

Studies on fish, mice, and worms and flies have shown that lifespan, and healthy lifespan, can be prolonged by 60%, 25%, and 30% respectively using Resveratrol and a normal calorie diet. Even more impressive is that these studies have shown that 1) animals also lived healthier lives due to the prevention and/or delay of the onset of age-related diseases such as diabetes, neurological disorders, heart disease, and cancer, and 2) even obese animals, who would normally have many complications, lived normal-aged lives.

Resveratrol and red grape polyphenols are “all the rage” these days, and supply and demand is growing in leaps and bounds in terms of its inclusion in supplements, foods, drinks, etc. However, it should again be noted that while Resveratrol has the highest SIRT gene activation, other polyphenols found in red wine grapes such as Quercetin and Catechins, are not far behind, and work in concert with Resveratrol.

Latest Medical Research

Extensive medical research has been conducted by university professors, pharmaceutical companies, and nutraceutical companies into the medical benefits of red wine extracts, Quercetin, and Resveratrol ingredients.

These studies have shown many health benefits including: anti-inflammatory, blood thinning and reduced risk for artery clotting (anti-coagulant), normalization of blood sugar (for diabetes), increase mental capacity and memory, increase in strength and endurance, removal of amyloid-beta proteins that may cause brain damage associated with Alzheimer’s, and even the inhibition of many types of cancers (lung, colon, skin, liver and pancreatic).

Can it really be that all of these age-related issues may be dealt with using simply plant polyphenols compounds? Quite possibly, the answer is yes.

Excerpt:

Resveratrol – The Miracle Nutrient for Cancer, Cholesterol and Longevity

(NaturalNews) You’ve all heard the good news about resveratrol, commonly known as the “red wine nutrient.” There’s more to resveratrol than red wine, though, and it’s helpful for far more than just preventing heart disease. It’s also phenomenal for maintaining a healthy cholesterol balance and even supporting increased longevity.

As you’ll see below in quotes from health experts about resveratrol, this “miracle” nutrient is also useful for preventing many types of cancer. As you read these quotes, pay special attention to any mention of phytoalexins, as this is a class of plant-based nutrients that you’ll be hearing about much more in the future (as nutritional healing becomes more widely known).

If you want to acquire some resveratrol, there are lots of natural sources such as red wine or grape leaves (the leaves actually contain far more than the grapes themselves). The Chinese medicine herb hu zhang is also loaded with resveratrol.

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Among other topics:

• Aging
  • Damage to DNA
  • Error Theories
  • Stress, Depression, etc.
• Articles
  • All about Resveratrol
• Calorie Restriction
  • Human Evidence
• Competitive Products
• Foods and Drinks
  • Balanced Diet
  • Cancer Causing Foods
  • Dark Chocolate
  • Dr. Maroon’s Recommendations
  • Green Tea
• Grapes and Red Wine
  • Grape Seed Extract & Colon Cancer
  • Resveratrol, Wine or Grapes?
• Green Tea
  • Diabetes
  • Green Tea Benefits
• Longevity
• Medical Benefits
  • Arthritis
  • Baseline Medical Evaluation
  • Increased Energy Level
  • Leukaemia
  • Liver Protection
• Pharmaceuticals
• Polyphenols
• Quercetin
• Red Wine Grape Extracts
  • Clinical Trials
  • Muscadine Grapes
• Resveratrol
  • Resveratrol Dosage
  • Safety
  • Sources of Resveratrol
• Scientific Research

Joseph Maroon, MD

University of Pittsburgh School of Medicine

Bottom Line Heath, September 2009

The Simple Supplement that

May Prevent Killer Diseases

All about resveratrol

When it comes to “hot” supplements, resveratrol is high on the list. Multiple studies conducted on laboratory animals have demonstrated the highly beneficial effects on this polyphenol (a class of plant chemicals), which is found most abundantly in the skins of grapes and in red wine – and now is available in supplement form.

Key animal findings: Resveratrol has been shown not only to enhance muscle strength and reduce fatigue, but also to help prevent heart disease, stroke, diabetes and cancer … clear away the toxic proteins that cause Alzheimer’s disease … and even lengthen life span by 25%.

But can this substance do the same for humans?

AN IMPORTANT DISCOVERY

Resveratrol’s emergence as an anti-aging and disease-fighting powerhouse began in the 1930s with a seemingly unrelated finding – that sever calorie restriction extended the lives of rodents by 40 to 50%.

It wasn’t until the 1990s, however, that researchers from Harvard Medical School discovered the genetic basis for the beneficial effect of calorie restriction. Through various experiments in animal studies, calorie restriction was shown to trigger a kind of chain reaction that activates “survival genes” (sirtuins), which, in turn, energize an enzyme (SIR2) that stabilizes DNA. This process slows cellular aging.

In further studies, researchers discovered that resveratrol is one of the most potent sources of the molecules that activate these survival genes.

CURRENT EVIDENCE

To further test resveratrol’s benefits, researchers conducted other animal studies – this time without calorie restriction. Resveratrol and other polyphenols were found to increase the life span of fish by 60% … worms and flies by 30% … and mice by 25% — benefits attributed to improved cellular health.

Resveratrol-enhanced cells are believed to help fight …

Hearth disease and stroke. Resveratrol appears to decrease harmful inflammation, which contributes to cardiovascular disease.

Breakthrough research: A human study showed that drinking one-and-a-half glasses of red wine a day lowered, by 40%, level of lipid peroxide, a by-product of inflammation that damages arteries. This and other health benefits are believed to be due to resveratrol and several other polyphenols in red wine.

Through various animal studies, resveratrol was shown to spark the production of the beneficial gas nitric oxide, which gives blood vessels more flexibility. Resveratrol also thins the blood, reducing the risk for artery-clogging clot. In studies of animals with induced heart attacks, those given resveratrol had a significantly lower fatality rate. In similar studies on stroke, resveratrol prevented paralysis and limited brain injury in animals.

Cancer. Eighteen different types of cancer – including lung, colon, skin, liver, and pancreatic – have been markedly inhibited by resveratrol in laboratory studies using both animal and human cells.

Diabetes. In animals, resveratrol helps normalize blood sugar (glucose) levels by moving glucose out of the bloodstream into cells. Laboratory research also shows that resveratrol reduces diabetic neuropathy (nerve pain that often occurs in the legs and feet).

New finding: In human study, a synthetic, resveratrol-like compound was shown to give people the same type of glucose control that resveratrol gives mice.

Alzheimer’s disease: In animal studies, resveratrol helps remove the amyloid-beta protein that causes the brain damage associated with Alzheimer’s disease.

New finding: In a study of 90 healthy people, researchers at Marywood University in Scranton found that a supplement containing resveratrol and other polyphenols improved memory and sped up reaction time.

RESVERATROL SOURCES

Even though the preliminary research is promising, there is a caveat. You would have to drink up to 1,150 bottles of red wine daily to get the amount of resveratrol used in most animal studies.

Since that’s not feasible, I recommend a more practical approach that includes two things – a regular diet of resveratrol and polyphenol-rich foods (the resveratrol is far lower than the doses used in animal studies, but these foods contain other beneficial compounds that may enhanced absorption of resveratrol from food and/or supplements) … and the use of a mixed polyphenol supplement or a resveratrol supplement.

That synergy – along with regular exercise and a lifestyle that includes the heath-promoting effects of close emotional ties with family and friends – is your best bet for fighting chronic disease and living longer. My advice …

Eat a polyphenol-rich diet. Resveratrol is the superstar of polyphenols, but many scientists think that a combination of polyphenols – ingesting them together, as they are found in nature – is the best way to activate survival genes.

The foods richest in resveratrol and a variety of other polyphenols …

Red wine or red grape juice. These are the top dietary sources of resveratrol. Important: Wine grapes with the most resveratrol include pinot noir, merlot, Grenache, cabernet sauvignon and tempranillo. (These wines also deliver up to about 500 different polyphenols along with resveratrol.) Suggested daily intake: Four to 16 ounces of red grape juice daily (be mindful of the sugar content). Up to 12 ounces of red wine daily for men … and no more than six ounces daily for women (the potential health benefit of daily wine consumption by women must be weighed against a possible increase in breast cancer risk).

Pomegranate juice. It is a good source of resveratrol and many other antioxidants. Suggested daily intake:  Three to five ounces.

Dark chocolate. It is a rich source of concentrated flavonols, a potent type of polyphenol. Select unsweetened or semi-sweetened varieties with at least 70% cocoa. Suggested inake: One bite-sized square.

Green tea. Green tea contains resveratrol and is rich in epigallo-catechin gallate (EGCG) and other polyphenols. Suggested daily intake: Three eight-ounce cups. Decaffeinated green tea contains EGCG but relatively little resveratrol.

Blueberries. They are rich in procyanidins and other polyphenols. Suggested daily intake: At least one cup (fresh or frozen).

Take a mixed-polyphenol supplement. I recommend the mixed polyphenol supplement Vindure 900, a product developed by Vinomis Laboratories based on Harvard University research. Vindure is available from Vinomis Laboratories (877-484-6664, www.vinomis.com). Cost: $40 for 30 tablets. Follow the dosage recommendation on the label.

Because resveratrol absorption is though to be enhanced when combined with other natural polyphenols, a mixed-polyphenol supplement is best.

However, an alternative is to …

Take a resveratrol supplement. There are more than 300 resveratrol-containing products now available. The best products are made with trans-resveratrol (the active form of the substance shown by professional testing to activate the sirtuin “survival genes”) … and produced by manufacturers who comply with “Good Manufacturing Practices” (GMP), which ensures that the product contains no major contaminants.

My favorite resveratrol products are manufactured by …

Longevinex, www.longevinex.com, 866-405-4000 … 30 capsules for $37.

RevGenetics, at www.myrevgenetics.com, 888-738-4363 … 30 capsules for $43.

Suggested intake for most resveratrol supplements: 250 mg to 500 mg daily.

Bottom Line/Health interviewed Joseph Maroon, MD a professor of neurological surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh School of Medicine and team neurosurgeon for the Pittsburgh Steelers. He is the author of The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life (Atria). www.josephmaroon.com.  

READ ARTICLE in Neutraceutical World – Click Here

‘Stressed Plant’ Technology Comes to Fruition

 

Vindure 900 is billed to contain the highest dosage of Resveratrol on the market.

 

By Joanna Cosgrove 
Online Editor

 

Last November, Nutraceuticals World detailed how Pittsburgh, PA-based Xenomis LLC had licensed Harvard Medical School’s “Stressed Plant” technology with the goal of developing cutting edge resveratrol supplement applications. Flash forward to the present and there is a new supplement that boasts the highest resveratrol content of any product currently on the market. 

The product evolved out of the phenomenon known as “The French Paradox,” whereby the French live longer and healthier than Americans, despite a high saturated fat, high calorie diet, thanks apparently to the consumption of red wine. In 2003, a team of researchers at Harvard Medical School “broke the code” and discovered that 19 polyphenols activate the “SIRT” genes, and 17 of these are found in red grapes and red wine. SIRT genes produce the Sirtuin enzymes which play a key role in the aging process, and prevent many of the diseases related to aging such as diabetes, cancers, heart disease, Alzheimer’s and others.

The Harvard Medical School researchers concluded that two of the most powerful SIRT activators were Resveratrol and Quercetin. Together with an advisory board of distinguished physicians and researchers, Sewickley, PA-based Vinomis Laboratories, a spinoff company of Xenomis LLC, developed an ideal combination of these ingredients, a product called Vindure 900.

Launched in mid-June, the product is a powerful antioxidant cocktail containing 400 mg of 98% pure Resveratrol, 400 mg of red wine grape extract from Bordeaux, France, and 100 mg of high-purity Quercetin which, in addition to its own benefits, enhances the bio-availability of the Resveratrol, keeping it in the bloodstream longer. The formulation provides more than 900 mg of active ingredients in a one-per-day coated tablet.

The company said the product is “the equivalent of 100 bottles of red wine,” sans the alcohol or calories.

“[It] is the combination of Resveratrol, Quercetin and Red Wine grape polyphenols that provide the health benefits and increase the bioavailability,” explained Mark Juliano, president, Vinomis Laboratories. He added that the source of the pure resveratrol is 98% pure Polygonum cuspidatum (Japanese Knotweed), as well as that contained in the Red Wine grape extract. “This is a very expensive ingredient at over $700 per kg. Most resveratrol is either synthetic, or is only 50% pure (of course it’s the ‘other’ 50% that’s the impurities),” he said.

Independent tests conducted by Brunswick Laboratories of Norton, MA, measured the ORAC (oxygen radical absorbance capacity) of Vindure at 19,638, which is more thansix times times over the USDA recommended daily consumption of at least 3000 ORAC units—roughly equal to eight times the amount of antioxidants in a glass of pomegranate juice.

Clinical Support

One of the most exciting aspects of the product, according to Mr. Juliano, is the breadth of support it has received from human clinical trials. Most notably, in 2006 Dr. James Smoliga, professor of Exercise Physiology, College of Health and Human Services at Marywood University, studied the product’s exact combination of ingredients on human subjects. He reported that the subjects showed “dramatic increases in strength, endurance and memory/cognition.”

The Vinomis team is also eagerly awaiting the results from two current studies. Dr. Smoliga is presently testing Naturex Powergrape (which Mr. Juliano characterized as a key part of Vinomis’ grape extract), but plans a “follow on study” with Vindure 900 as it relates to endurance in human athletes. Strength, endurance, memory plus sirtuin levels, sugar levels and other biomarkers will all be examined.

Dr. Bryan Donohue, chief of cardiology at the University of Pittsburgh Medical Center, and Dr. Joseph Baur of the University of Pennsylvania School of Medicine’s Institute for Diabetes, Obesity and Metabolism, Department of Physiology, are also studying pre- and post-Vindure 900 sugar, cholesterol, Sirtuin and Resveratrol levels in human blood.

Regarding Vindure 900 patient results, Mr. Juliano said the company has been collecting patient results through a select group of doctors for several months. “We all know the long-term benefits of Resveratrol, Quercetin and Red Wine grape extracts, but we’re also getting a number of short-term results,” he said. The company’s study is ongoing, however the results so far confirm that more than 50% of patients report that after taking Vindure 2-4 weeks they’ve experienced “increased energy level (80%+), improved mental clarity, improved mood level (elimination of depression in some cases), lower appetite and weight loss.”

He added that there have also been reports of “moderation and/or lowering of blood sugar levels, lowering of cholesterol levels, [and] increased urination on patient with prostrate issues.” The only side effects noted are less sleep, though the patients attributed it to increased energy levels. “This effect is eliminated if patients take Vindure 900 in the morning,” said Mr. Juliano, and he added that the product should be taken with food.

Vindure 900 is being marketed primarily toward consumers (especially athletes and Baby Boomers) seeking to alleviate “age-related diseases” while benefitting from “increased energy” and “improved cognition.” The product is also targeting high-risk patients with elevated cholesterol, lipid and blood sugar levels via physician recommendations.

Vindure 900 is sold on Vinomis’ website, through doctors and in select pharmacies. A 30-day supply of the product (30 tablets) retails for $39.95. Mr. Juliano said there are also “deals in the works” with major nutritional supplement chains.

Vindure 900 is manufacturerd in the U.S. for Vinomis by Nutra Manufacturing of Greenville, SC, a subsidiary of General Nutrition Centers (GNC). The facility is certified by FDA, Australian TGA, USP and NSF, and complies with the latest GMPs.

Mr. Juliano and his partners—Bill Watts, formerly the CEO of GNC, David Sculley, formerly the CEO of Heinz, Dr. Brian Donohue and Dr. Joseph Maroon, Chief of Neurosurgery, UPMC—are keenly aware that consumers prefer proof over empty promises when it comes to nutritional supplements and are eager to see how the public receives their flagship Vindure 900 product. For more information about the science supporting the product, logon to Vinomis Laboratories’ website.

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