Muscadine grapes are native to North America, and may be the only fruit that originated in America and nowhere else. These grapes grow almost exclusively in southeastern United States mostly in Georgia, South Carolina, Alabama and Florida. Triving under adverse conditions due to their thicker and tougher skin.

Muscadine grapes have an extra chromosome that may allow the grapes to produce a unique phytochemical ellagic acid, which is a polyphenol compound absent in many other grapes. Ellagic acid is a powerful antioxidant, much like Resveratrol, Quercetin, and others. 

Muscadine grapes have been studied in organisms, animals and humans and have shown positive results in the areas of cancer, heart disease, high cholesterol, diabetes, and other inflammatory conditions.  The Resveratrol content in Muscadine grapes is higher than many other Red Wine grapes, although extracts from Pinot Noir, Cabernet, Bordeaux, and others also have a very high percent concentration of Resveratrol and other polyphenols.