Vinomis exclusive Harvard Medical School license for proprietary science
Vinomis Laboratories has worked with Harvard Medical School and formulated its products using various elements of Harvard's proprietary science patent - XENOHORMESIS BASED COMPOSITIONS AND METHODS (U.S. provisional application 60/758,703 filed January 13, 2006).
In Harvard's scientific research and associated patent, scientists discovered several essential pieces of the polyphenoland Resveratrol puzzle. The scientists found that when certain plants are put into a stressed xenohormeticenvironment (dehydration, infection, heat, cold, extreme UV exposure, etc.) they produce compounds called polyphenols, which include resveratrol, Quercetin, catchetin, etc. When these compounds are ingested by animals, they produce similar results to those under a calorie restricted diet. (increased longevity, lower incidence of age-related diseases, etc.) The pathway to these benefits is theorized to be through the up-regulation (increase) of the Sirtuin genes and enzymes.
These same scientists studied thousands of plant molecules and compounds and showed that 19 plant polyphenols provided the greatest increase in sirtuin genes. Of these, 17 were found to be prevalent in red wine grapes, with Resveratrol exhibiting the greatest impact, athough other polyphenols also provide significant impact.
Separately, wine makers throughout the world have known for centuries that some of the best wines are produced from vines that have the lowest crop yields, due essentially to a concentration of flavors in the remaining grapes. When grape vines are placed under a variety of stress conditions, they indeed reduce their yield, and improve their flavor. Not surprisingly, wine makers in some of the greatest wine regions in the world in France, Italy, Australia, and California, use stressed grape vine practices to produce superior wine.
In the development and formulation of its nutraceutical supplement products, Vinomis has considered many factors including: 1) exclusive Harvard Medical School science and contact with Harvard professors, 2) understanding of red wine grape growing techniques and science, 3) clinical trials conducted at Universities using the same combination of ingredients found in Vindure, and 4) generally published scientific and medical research.
For example, Vindure includes both Resveratrol and Quercetin, found to be up-regulating agents by Harvard scientists, as well as the finest red wine grape extracts from Bordeaux, France, which guarantee the inclusion of all 17 of the polyphenols studied at Harvard.
"...molecules such as catchetin, quercetin, and pterostilbene[all polyphenols] are beneficial alone and may have additive or even synergistic effects in combination with resveratrol."
Harvard Medical School patent
Below are excerpts from the Harvard Patent - XENOHORMESIS BASED COMPOSITIONS AND METHODS (U.S. provisional application 60/758,703 filed January 13, 2006).
See the entire patent information at:
Entire Patent
PATENT EXCERPTS:
"There is now good evidence from model organisms that the pace of aging can be regulated...Longevity regulatory genes have been identified in many eukaryotes, including rodents, flies, nematode worms and even single-celled organisms such as baker's yeast ... These genes appear to be part of an evolutionarily conserved longevity pathway that evolved to promote survival in response to deteriorating environmental conditions or stress...Stress may include starvation, irradiation, heat or toxin exposure ... Resveratrol (3,5,4-trihydroxystilbene), a constituent of red wine, has been identified to activate sirtuin deacetylase and to extend the life spans of lower organisms..."
"...Studies on caloric restriction have thoroughly established that organisms, including mammals, are capable of entering a state of increased stress-resistance that improves health and survival when energy intake is low (1,2). From an evolutionary standpoint, it has been suggested that this might represent an adaptive response to changing environmentalconditions..."
"...Xenohormetic molecules include molecules that are produced in plants or products thereof, such as fruit, vegetables, flowers, and grains, in response to a stress condition. Stress may be any non-optimal condition for growth, development or reproduction, or a non-physiological condition, e.g., heat, dehydration, infection, starvation, irradiation, injury, excessive light, and cold..."
"...Although none have yet been studied in as much detail, molecules such as catchetin, quercetin, and pterostilbene are beneficial alone and may have additive or even synergistic effects in combination with resveratrol."
"...Since xenohormesis predicts that animals have adapted to respond in a particular way to the presence of phytochemicals from stressed plantsÂ…we can predict that a variety of different molecules (even when structurally unrelated) should produce similar effects. By screening a large number of these molecules against panels of enzyme activities or gene expression patterns, we should be able to determine a consensus pattern that corresponds to the healthier state induced by phytochemicals from stressed plants. Our invention would involve the identification of this pattern and its use to evaluate potential xenohormetic molecules, and design new drugs that might tap into pathways related to xenohormesis..."
"...Xenohormetic molecules can have multiple independent effects (e.g., reservatrol and quercetin both activate sitruins and inhibit kinases) and can even accomplish the same beneficial effects through multiple mechanisms..."
