In Harvard's scientific research and associated patent, scientists discovered several essential pieces of the polyphenoland Resveratrol puzzle. The scientists found that when certain plants are put into a stressed xenohormeticenvironment (dehydration, infection, heat, cold, extreme UV exposure, etc.) they produce compounds called polyphenols, which include resveratrol, Quercetin, catchetin, etc. When these compounds are ingested by animals, they produce similar results to those under a calorie restricted diet. (increased longevity, lower incidence of age-related diseases, etc.) The pathway to these benefits is theorized to be through the up-regulation (increase) of the Sirtuin genes and enzymes.
These same scientists studied thousands of plant molecules and compounds and showed that 19 plant polyphenols provided the greatest increase in sirtuin genes. Of these, 17 were found to be prevalent in red wine grapes, with Resveratrol exhibiting the greatest impact, athough other polyphenols also provide significant impact.
Separately, wine makers throughout the world have known for centuries that some of the best wines are produced from vines that have the lowest crop yields, due essentially to a concentration of flavors in the remaining grapes. When grape vines are placed under a variety of stress conditions, they indeed reduce their yield, and improve their flavor. Not surprisingly, wine makers in some of the greatest wine regions in the world in France, Italy, Australia, and California, use stressed grape vine practices to produce superior wine.
In the development and formulation of its nutraceutical supplement products, Vinomis has considered many factors including: 1) contact with Harvard professors, 2) understanding of red wine grape growing techniques and science, 3) clinical trials conducted at Universities using the same combination of ingredients found in Vindure, and 4) generally published scientific and medical research.
For example, Vindure includes both Resveratrol and Quercetin, found to be up-regulating agents by Harvard scientists, as well as the finest red wine grape extracts from Bordeaux, France, which guarantee the inclusion of all 17 of the polyphenols studied at Harvard.
"...molecules such as catchetin, quercetin, and pterostilbene[all polyphenols] are beneficial alone and may have additive or even synergistic effects in combination with resveratrol."
